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Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice

Overview of attention for article published in Particle and Fibre Toxicology, April 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Citations

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92 Mendeley
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Title
Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice
Published in
Particle and Fibre Toxicology, April 2018
DOI 10.1186/s12989-018-0254-4
Pubmed ID
Authors

Yu-Chi Chang, Toby B. Cole, Lucio G. Costa

Abstract

Escalating prevalence of autism spectrum disorders (ASD) in recent decades has triggered increasing efforts in understanding roles played by environmental risk factors as a way to address this widespread public health concern. Several epidemiological studies show associations between developmental exposure to traffic-related air pollution and increased ASD risk. In rodent models, a limited number of studies have shown that developmental exposure to ambient ultrafine particulates or diesel exhaust (DE) can result in behavioral phenotypes consistent with mild ASD. We performed a series of experiments to determine whether developmental DE exposure induces ASD-related behaviors in mice. C57Bl/6J mice were exposed from embryonic day 0 to postnatal day 21 to 250-300 μg/m3 DE or filtered air (FA) as control. Mice exposed developmentally to DE exhibited deficits in all three of the hallmark categories of ASD behavior: reduced social interaction in the reciprocal interaction and social preference tests, increased repetitive behavior in the T-maze and marble-burying test, and reduced or altered communication as assessed by measuring isolation-induced ultrasonic vocalizations and responses to social odors. These findings demonstrate that exposure to traffic-related air pollution, in particular that associated with diesel-fuel combustion, can cause ASD-related behavioral changes in mice, and raise concern about air pollution as a contributor to the onset of ASD in humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 92 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 22%
Student > Master 12 13%
Researcher 11 12%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 12 13%
Unknown 24 26%
Readers by discipline Count As %
Medicine and Dentistry 15 16%
Neuroscience 13 14%
Psychology 10 11%
Nursing and Health Professions 8 9%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 14 15%
Unknown 27 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2023.
All research outputs
#3,054,414
of 25,552,205 outputs
Outputs from Particle and Fibre Toxicology
#108
of 617 outputs
Outputs of similar age
#60,089
of 340,932 outputs
Outputs of similar age from Particle and Fibre Toxicology
#6
of 13 outputs
Altmetric has tracked 25,552,205 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,932 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.