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A genetic analysis of Trichuris trichiura and Trichuris suis from Ecuador

Overview of attention for article published in Parasites & Vectors, March 2015
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  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Title
A genetic analysis of Trichuris trichiura and Trichuris suis from Ecuador
Published in
Parasites & Vectors, March 2015
DOI 10.1186/s13071-015-0782-9
Pubmed ID
Authors

Hayley Meekums, Mohamed BF Hawash, Alexandra M Sparks, Yisela Oviedo, Carlos Sandoval, Martha E Chico, J Russell Stothard, Philip J Cooper, Peter Nejsum, Martha Betson

Abstract

Since the nematodes Trichuris trichiura and T. suis are morphologically indistinguishable, genetic analysis is required to assess epidemiological cross-over between people and pigs. This study aimed to clarify the transmission biology of trichuriasis in Ecuador. Adult Trichuris worms were collected during a parasitological survey of 132 people and 46 pigs in Esmeraldas Province, Ecuador. Morphometric analysis of 49 pig worms and 64 human worms revealed significant variation. In discriminant analysis morphometric characteristics correctly classified male worms according to host species. In PCR-RFLP analysis of the ribosomal Internal Transcribed Spacer (ITS-2) and 18S DNA (59 pig worms and 82 human worms), nearly all Trichuris exhibited expected restriction patterns. However, two pig-derived worms showed a "heterozygous-type" ITS-2 pattern, with one also having a "heterozygous-type" 18S pattern. Phylogenetic analysis of the mitochondrial large ribosomal subunit partitioned worms by host species. Notably, some Ecuadorian T. suis clustered with porcine Trichuris from USA and Denmark and some with Chinese T. suis. This is the first study in Latin America to genetically analyse Trichuris parasites. Although T. trichiura does not appear to be zoonotic in Ecuador, there is evidence of genetic exchange between T. trichiura and T. suis warranting more detailed genetic sampling.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Malaysia 1 1%
Indonesia 1 1%
Denmark 1 1%
United States 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 21%
Student > Master 12 15%
Student > Ph. D. Student 8 10%
Researcher 7 9%
Student > Postgraduate 4 5%
Other 13 17%
Unknown 18 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 19%
Biochemistry, Genetics and Molecular Biology 10 13%
Veterinary Science and Veterinary Medicine 9 12%
Medicine and Dentistry 6 8%
Immunology and Microbiology 6 8%
Other 11 14%
Unknown 21 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2015.
All research outputs
#14,219,838
of 22,796,179 outputs
Outputs from Parasites & Vectors
#2,823
of 5,460 outputs
Outputs of similar age
#139,171
of 263,733 outputs
Outputs of similar age from Parasites & Vectors
#46
of 120 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,460 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,733 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.