Title |
Multi-drugs resistant acne rosacea in a child affected by Ataxia-Telangiectasia: successful treatment with Isotretinoin
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Published in |
Italian Journal of Pediatrics, March 2015
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DOI | 10.1186/s13052-015-0125-7 |
Pubmed ID | |
Authors |
Nicoletta Cantarutti, Alessia Claps, Giulia Angelino, Luciana Chessa, Francesco Callea, May El Hachem, Andrea Diociaiuti, Andrea Finocchi |
Abstract |
Ataxia-Telangiectasia is a rare multisystem autosomal recessive disorder [OMIM 208900], caused by mutations in Ataxia-Telangiectasia Mutated gene. It is characterized by neurological, immunological and cutaneous involvement. Granulomas have been previously reported in Ataxia-Telangiectasia patients, even if acne rosacea has not been described.We report a case of a young Ataxia-Telangiectasia patient with a severe immunological and neurological involvement, who developed granulomatous skin lesions diagnosed by skin biopsy as acne rosacea. Considering the severe clinical picture and the lack of improvement to multiple topic and systemic therapies, treatment with Isotretinoin was started and the skin lesions disappeared after five months. However the therapy was stopped due to drug-hepatotoxicity.Systemic treatment with Isotretinoin should be carefully considered in patient with Ataxia-Telangiectasia for the treatment of multi-drug resistant acne rosacea, however its toxicity may limit long-term use and the risk/benefit ratio of the treatment should be evaluated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 15% |
Student > Master | 2 | 15% |
Lecturer | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Other | 1 | 8% |
Other | 3 | 23% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 46% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Environmental Science | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Engineering | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 23% |