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Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis

Overview of attention for article published in Molecular Cancer, August 2010
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Title
Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
Published in
Molecular Cancer, August 2010
DOI 10.1186/1476-4598-9-206
Pubmed ID
Authors

Pawan Kumar, Arti Yadav, Samip N Patel, Mozaffarul Islam, Quintin Pan, Sofia D Merajver, Theodoros N Teknos

Abstract

The metastatic spread of solid tumors is directly or indirectly responsible for most cancer-related deaths. Tumor metastasis is very complex and this process requires a tumor cell to acquire enhanced motility, invasiveness and anoikis resistance to successfully establish a tumor at a distal site. Metastatic potential of tumor cells is directly correlated with the expression levels of several angiogenic cytokines. Copper is a mandatory cofactor for the function of many of these angiogenic mediators as well as other proteins that play an important role in tumor cell motility and invasiveness. We have previously shown that tetrathiomolybdate (TM) is a potent chelator of copper and it mediates its anti-tumor effects by suppressing tumor angiogenesis. However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
India 1 2%
United States 1 2%
Australia 1 2%
Unknown 41 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 27%
Student > Ph. D. Student 11 24%
Professor 4 9%
Student > Bachelor 3 7%
Other 3 7%
Other 5 11%
Unknown 7 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 31%
Biochemistry, Genetics and Molecular Biology 10 22%
Medicine and Dentistry 8 18%
Chemistry 3 7%
Engineering 2 4%
Other 1 2%
Unknown 7 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2011.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Molecular Cancer
#1,230
of 1,918 outputs
Outputs of similar age
#85,307
of 104,161 outputs
Outputs of similar age from Molecular Cancer
#34
of 36 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.