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Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses

Overview of attention for article published in Biotechnology for Biofuels and Bioproducts, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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3 X users
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1 patent

Citations

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147 Dimensions

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203 Mendeley
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Title
Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Published in
Biotechnology for Biofuels and Bioproducts, March 2015
DOI 10.1186/s13068-015-0227-x
Pubmed ID
Authors

Noppon Lertwattanasakul, Tomoyuki Kosaka, Akira Hosoyama, Yutaka Suzuki, Nadchanok Rodrussamee, Minenosuke Matsutani, Masayuki Murata, Naoko Fujimoto, Suprayogi, Keiko Tsuchikane, Savitree Limtong, Nobuyuki Fujita, Mamoru Yamada

Abstract

High-temperature fermentation technology with thermotolerant microbes has been expected to reduce the cost of bioconversion of cellulosic biomass to fuels or chemicals. Thermotolerant Kluyveromyces marxianus possesses intrinsic abilities to ferment and assimilate a wide variety of substrates including xylose and to efficiently produce proteins. These capabilities have been found to exceed those of the traditional ethanol producer Saccharomyces cerevisiae or lignocellulose-bioconvertible ethanologenic Scheffersomyces stipitis. The complete genome sequence of K. marxianus DMKU 3-1042 as one of the most thermotolerant strains in the same species has been determined. A comparison of its genomic information with those of other yeasts and transcriptome analysis revealed that the yeast bears beneficial properties of temperature resistance, wide-range bioconversion ability, and production of recombinant proteins. The transcriptome analysis clarified distinctive metabolic pathways under three different growth conditions, static culture, high temperature, and xylose medium, in comparison to the control condition of glucose medium under a shaking condition at 30°C. Interestingly, the yeast appears to overcome the issue of reactive oxygen species, which tend to accumulate under all three conditions. This study reveals many gene resources for the ability to assimilate various sugars in addition to species-specific genes in K. marxianus, and the molecular basis of its attractive traits for industrial applications including high-temperature fermentation. Especially, the thermotolerance trait may be achieved by an integrated mechanism consisting of various strategies. Gene resources and transcriptome data of the yeast are particularly useful for fundamental and applied researches for innovative applications.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
Indonesia 1 <1%
Latvia 1 <1%
Canada 1 <1%
Korea, Republic of 1 <1%
Thailand 1 <1%
United States 1 <1%
Unknown 195 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 19%
Student > Master 36 18%
Researcher 32 16%
Student > Bachelor 24 12%
Student > Doctoral Student 13 6%
Other 25 12%
Unknown 34 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 31%
Biochemistry, Genetics and Molecular Biology 61 30%
Engineering 7 3%
Chemical Engineering 7 3%
Immunology and Microbiology 4 2%
Other 17 8%
Unknown 44 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2023.
All research outputs
#6,238,302
of 25,373,627 outputs
Outputs from Biotechnology for Biofuels and Bioproducts
#366
of 1,578 outputs
Outputs of similar age
#70,639
of 291,325 outputs
Outputs of similar age from Biotechnology for Biofuels and Bioproducts
#14
of 42 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,578 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,325 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.