Title |
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
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Published in |
BMC Biology, September 2011
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DOI | 10.1186/1741-7007-9-65 |
Pubmed ID | |
Authors |
Federica Parisi, Sara Riccardo, Margaret Daniel, Mahesh Saqcena, Nandini Kundu, Annalisa Pession, Daniela Grifoni, Hugo Stocker, Esteban Tabak, Paola Bellosta |
Abstract |
Genetic studies in Drosophila melanogaster reveal an important role for Myc in controlling growth. Similar studies have also shown how components of the insulin and target of rapamycin (TOR) pathways are key regulators of growth. Despite a few suggestions that Myc transcriptional activity lies downstream of these pathways, a molecular mechanism linking these signaling pathways to Myc has not been clearly described. Using biochemical and genetic approaches we tried to identify novel mechanisms that control Myc activity upon activation of insulin and TOR signaling pathways. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Sweden | 1 | <1% |
Germany | 1 | <1% |
Spain | 1 | <1% |
India | 1 | <1% |
Unknown | 104 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 45 | 41% |
Student > Master | 16 | 15% |
Researcher | 16 | 15% |
Student > Doctoral Student | 8 | 7% |
Student > Bachelor | 5 | 5% |
Other | 8 | 7% |
Unknown | 12 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 53 | 48% |
Biochemistry, Genetics and Molecular Biology | 34 | 31% |
Neuroscience | 4 | 4% |
Immunology and Microbiology | 2 | 2% |
Medicine and Dentistry | 2 | 2% |
Other | 2 | 2% |
Unknown | 13 | 12% |