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Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

Overview of attention for article published in BMC Biology, September 2011
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Title
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
Published in
BMC Biology, September 2011
DOI 10.1186/1741-7007-9-65
Pubmed ID
Authors

Federica Parisi, Sara Riccardo, Margaret Daniel, Mahesh Saqcena, Nandini Kundu, Annalisa Pession, Daniela Grifoni, Hugo Stocker, Esteban Tabak, Paola Bellosta

Abstract

Genetic studies in Drosophila melanogaster reveal an important role for Myc in controlling growth. Similar studies have also shown how components of the insulin and target of rapamycin (TOR) pathways are key regulators of growth. Despite a few suggestions that Myc transcriptional activity lies downstream of these pathways, a molecular mechanism linking these signaling pathways to Myc has not been clearly described. Using biochemical and genetic approaches we tried to identify novel mechanisms that control Myc activity upon activation of insulin and TOR signaling pathways.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Sweden 1 <1%
Germany 1 <1%
Spain 1 <1%
India 1 <1%
Unknown 104 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 41%
Student > Master 16 15%
Researcher 16 15%
Student > Doctoral Student 8 7%
Student > Bachelor 5 5%
Other 8 7%
Unknown 12 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 48%
Biochemistry, Genetics and Molecular Biology 34 31%
Neuroscience 4 4%
Immunology and Microbiology 2 2%
Medicine and Dentistry 2 2%
Other 2 2%
Unknown 13 12%