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An atlas of mouse CD4+ T cell transcriptomes

Overview of attention for article published in Biology Direct, April 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Citations

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79 Dimensions

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178 Mendeley
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2 CiteULike
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Title
An atlas of mouse CD4+ T cell transcriptomes
Published in
Biology Direct, April 2015
DOI 10.1186/s13062-015-0045-x
Pubmed ID
Authors

Michael JT Stubbington, Bidesh Mahata, Valentine Svensson, Andrew Deonarine, Jesper K Nissen, Alexander G Betz, Sarah A Teichmann

Abstract

CD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of several effector subtypes that exhibit distinct functions. The transcriptional mechanisms that underlie the specific functional identity of CD4(+) T cells are not fully understood. To assist investigations into the transcriptional identity and regulatory processes of these cells we performed mRNA-sequencing on three murine T helper subtypes (Th1, Th2 and Th17) as well as on splenic Treg cells and induced Treg (iTreg) cells. Our integrated analysis of this dataset revealed the gene expression changes associated with these related but distinct cellular identities. Each cell subtype differentially expresses a wealth of 'subtype upregulated' genes, some of which are well known whilst others promise new insights into signalling processes and transcriptional regulation. We show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation. This CD4(+) transcriptome atlas provides a valuable resource for the study of CD4(+) T cell populations. To facilitate its use by others, we have made the data available in an easily accessible online resource at www.th-express.org . This article was reviewed by Wayne Hancock, Christine Wells and Erik van Nimwegen.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Japan 1 <1%
United Kingdom 1 <1%
Luxembourg 1 <1%
Unknown 173 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 25%
Researcher 34 19%
Student > Master 27 15%
Student > Bachelor 13 7%
Student > Doctoral Student 12 7%
Other 18 10%
Unknown 29 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 25%
Immunology and Microbiology 37 21%
Biochemistry, Genetics and Molecular Biology 36 20%
Medicine and Dentistry 11 6%
Neuroscience 6 3%
Other 16 9%
Unknown 28 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2021.
All research outputs
#5,597,999
of 23,306,612 outputs
Outputs from Biology Direct
#192
of 493 outputs
Outputs of similar age
#64,188
of 265,219 outputs
Outputs of similar age from Biology Direct
#5
of 13 outputs
Altmetric has tracked 23,306,612 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 493 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,219 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.