Title |
High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice
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Published in |
Lipids in Health and Disease, February 2015
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DOI | 10.1186/s12944-015-0002-9 |
Pubmed ID | |
Authors |
Yuzaburo Uetake, Hitoshi Ikeda, Rie Irie, Kazuaki Tejima, Hiromitsu Matsui, Sayoko Ogura, Hong Wang, ShengYu Mu, Daigoro Hirohama, Katsuyuki Ando, Tatsuya Sawamura, Yutaka Yatomi, Toshiro Fujita, Tatsuo Shimosawa |
Abstract |
It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome. We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice. High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice. We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH. |
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Finland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 17% |
Student > Ph. D. Student | 6 | 17% |
Student > Master | 4 | 11% |
Researcher | 4 | 11% |
Other | 3 | 9% |
Other | 3 | 9% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 34% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Agricultural and Biological Sciences | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Philosophy | 1 | 3% |
Other | 4 | 11% |
Unknown | 9 | 26% |