Title |
Mini review: linkage between α-Synuclein protein and cognition
|
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Published in |
Translational Neurodegeneration, March 2015
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DOI | 10.1186/s40035-015-0026-0 |
Pubmed ID | |
Authors |
Huda Saleh, Ayeh Saleh, Hailan Yao, Jie Cui, Yong Shen, Rena Li |
Abstract |
α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein function could contribute to various neurodegenerative disorders, such as Parkinson's disease (PD), a disease with symptomatic progression of deterioration in motor and cognitive function. Recent studies show that the level of α -synuclein in cerebrospinal fluid (CSF) is highly correlated with speed of cognitive decline, suggesting a potential role of α-synuclein in cognitive function. In this mini review, we will be focus on literatures of α-synuclein in cognitive function in the non-diseased brain, as well as the impact that defective α-synuclein has on cognition in disease brain. This will be accomplished by assessing the effects of soluble α-synuclein, α-synuclein oligomers, and extracellular α-synuclein transport, on neurodegeneration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Italy | 1 | 2% |
Unknown | 50 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 37% |
Researcher | 6 | 12% |
Student > Bachelor | 3 | 6% |
Other | 3 | 6% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 15% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 27% |
Neuroscience | 11 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Psychology | 4 | 8% |
Medicine and Dentistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 9 | 17% |