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Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest - a prospective observational cohort study

Overview of attention for article published in Critical Care, December 2015
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Title
Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest - a prospective observational cohort study
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0856-2
Pubmed ID
Authors

Ulrike Holzinger, Richard Brunner, Heidrun Losert, Valentin Fuhrmann, Harald Herkner, Christian Madl, Fritz Sterz, Bruno Schneeweiß

Abstract

Targeted temperature management improves outcome after cardiopulmonary resuscitation. Reduction of resting energy expenditure might be one mode of action. Aim of this study was to correlate resting energy expenditure and substrate oxidation rates with targeted temperature management at 33°C and outcome in patients after cardiac arrest. This prospective, observational cohort study was performed at the department of emergency medicine and a medical intensive care unit of a university hospital. Patients after successful cardiopulmonary resuscitation undergoing targeted temperature management at 33°C for 24 hours with subsequent rewarming to 36°C and standardized sedation, analgesic and paralytic medication were included. Indirect calorimetry was performed 5 times within 48 h after cardiac arrest. Measurements were correlated to outcome with repeated measures ANOVA, linear and logistic regression analysis. In 25 patients resting energy expenditure decreased 20 (18-27) % at 33°C compared to 36°C without differences between outcome groups (favourable vs. unfavourable: 25 (21-26) vs. 21 (16-26); p = 0.5). In contrast to protein oxidation rate (favourable vs. unfavourable: 35 (11-68) g/day vs. 39 (7-75) g/day, p = 0.8) patients with favourable outcome had a significantly higher fat oxidation rate (139 (104-171) g/day vs. 117 (70-139) g/day, p < 0.05) and a significantly lower glucose oxidation rate (30 (-34-88) g/day vs. 77 (19-138) g/day; p < 0.05) as compared to patients with unfavourable neurological outcome. Targeted temperature management at 33°C after cardiac arrest reduces REE by 20% compared to 36°C. Glucose and fat oxidation rates differ significantly between patients with favourable and unfavourable neurological outcome. Clinicaltrials.gov NCT00500825 . Registered 11 July 2007.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Korea, Republic of 1 2%
Brazil 1 2%
Egypt 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Bachelor 9 14%
Student > Ph. D. Student 6 9%
Professor > Associate Professor 5 8%
Professor 5 8%
Other 19 29%
Unknown 12 18%
Readers by discipline Count As %
Medicine and Dentistry 38 58%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Nursing and Health Professions 3 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Unspecified 1 2%
Other 4 6%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2015.
All research outputs
#15,982,793
of 25,373,627 outputs
Outputs from Critical Care
#5,196
of 6,554 outputs
Outputs of similar age
#214,446
of 395,408 outputs
Outputs of similar age from Critical Care
#445
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,408 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.