Title |
Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol
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Published in |
BMC Neurology, February 2011
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DOI | 10.1186/1471-2377-11-29 |
Pubmed ID | |
Authors |
Anouk GW van Norden, Karlijn F de Laat, Rob AR Gons, Inge WM van Uden, Ewoud J van Dijk, Lucas JB van Oudheusden, Rianne AJ Esselink, Bastiaan R Bloem, Baziel GM van Engelen, Machiel J Zwarts, Indira Tendolkar, Marcel G Olde-Rikkert, Maureen J van der Vlugt, Marcel P Zwiers, David G Norris, Frank-Erik de Leeuw |
Abstract |
Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD become demented or get parkinsonism. This might be explained by the diversity of underlying pathology of both white matter lesions (WML) and the normal appearing white matter (NAWM). Both cannot be properly appreciated with conventional MRI. Diffusion tensor imaging (DTI) provides alternative information on microstructural white matter integrity. The association between SVD, its microstructural integrity, and incident dementia and parkinsonism has never been investigated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 36% |
United Kingdom | 2 | 18% |
Sweden | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 64% |
Scientists | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Netherlands | 2 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
Slovakia | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Poland | 1 | <1% |
Unknown | 250 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 46 | 17% |
Researcher | 39 | 15% |
Student > Master | 36 | 14% |
Student > Bachelor | 26 | 10% |
Professor > Associate Professor | 15 | 6% |
Other | 48 | 18% |
Unknown | 53 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 73 | 28% |
Neuroscience | 36 | 14% |
Psychology | 23 | 9% |
Agricultural and Biological Sciences | 14 | 5% |
Computer Science | 10 | 4% |
Other | 36 | 14% |
Unknown | 71 | 27% |