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Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation

Overview of attention for article published in BMC Biology, April 2015
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Title
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation
Published in
BMC Biology, April 2015
DOI 10.1186/s12915-015-0134-4
Pubmed ID
Authors

Max Hans-Peter Gay, Tomas Valenta, Patrick Herr, Lisette Paratore-Hari, Konrad Basler, Lukas Sommer

Abstract

β-catenin plays a central role in multiple developmental processes. However, it has been difficult to study its pleiotropic effects, because of the dual capacity of β-catenin to coordinate cadherin-dependent cell adhesion and to act as a component of Wnt signal transduction. To distinguish between the divergent functions of β-catenin during peripheral nervous system development, we made use of a mutant allele of β-catenin that can mediate adhesion but not Wnt-induced TCF transcriptional activation. This allele was combined with various conditional inactivation approaches. We show that of all peripheral nervous system structures, only sensory dorsal root ganglia require β-catenin for proper formation and growth. Surprisingly, however, dorsal root ganglia development is independent of cadherin-mediated cell adhesion. Rather, both progenitor cell proliferation and fate specification are controlled by β-catenin signaling. These can be divided into temporally sequential processes, each of which depends on a different function of β-catenin. While early stage proliferation and specific, Neurog2- and Krox20-dependent waves of neuronal subtype specification involve activation of TCF transcription, late stage progenitor proliferation and Neurog1-marked sensory neurogenesis are regulated by a function of β-catenin independent of TCF activation and adhesion. Thus, switching modes of β-catenin function are associated with consecutive cell fate specification and stage-specific progenitor proliferation.

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Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
France 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 9 20%
Student > Master 8 17%
Student > Bachelor 5 11%
Student > Doctoral Student 5 11%
Other 8 17%
Unknown 2 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 50%
Agricultural and Biological Sciences 12 26%
Medicine and Dentistry 5 11%
Neuroscience 3 7%
Unknown 3 7%