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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial
|
|---|---|
| Published in |
Critical Care, December 2015
|
| DOI | 10.1186/s13054-015-0828-6 |
| Pubmed ID | |
| Authors |
Marleen Straat, Marcella CA Müller, Joost CM Meijers, Mendi S Arbous, Angelique ME Spoelstra - de Man, Charlotte JP Beurskens, Margreeth B Vroom, Nicole P Juffermans |
| Abstract |
Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition. A prospective pre-defined sub-study of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. Statistic tests used were paired t-test or the Wilcoxon signed rank test. At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml, p = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, p = 0.01) and a decrease in factor VIII levels (from 246 to 246%, p < 0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, p < 0.01) and a concomitant decrease in von Willebrand (vWF) levels (from 474 to 423%, p < 0.01). A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13 which is capable of cleaving vWF. Trialregister.nl NTR2262 , registered 26 March 2010 and Clinicaltrials.gov NCT01143909 , registered 14 June 2010. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Puerto Rico | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Czechia | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 80 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 9 | 11% |
| Student > Ph. D. Student | 9 | 11% |
| Researcher | 9 | 11% |
| Student > Postgraduate | 8 | 10% |
| Student > Master | 8 | 10% |
| Other | 18 | 22% |
| Unknown | 22 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 57% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Arts and Humanities | 2 | 2% |
| Agricultural and Biological Sciences | 2 | 2% |
| Nursing and Health Professions | 1 | 1% |
| Other | 6 | 7% |
| Unknown | 22 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2015.
All research outputs
#15,739,010
of 25,373,627 outputs
Outputs from Critical Care
#5,130
of 6,554 outputs
Outputs of similar age
#209,661
of 395,397 outputs
Outputs of similar age from Critical Care
#428
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.