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snoRNAs are a novel class of biologically relevant Myc targets

Overview of attention for article published in BMC Biology, April 2015
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Title
snoRNAs are a novel class of biologically relevant Myc targets
Published in
BMC Biology, April 2015
DOI 10.1186/s12915-015-0132-6
Pubmed ID
Authors

Eva K Herter, Maria Stauch, Maria Gallant, Elmar Wolf, Thomas Raabe, Peter Gallant

Abstract

Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one of the main driving factors of human malignancies. They function as transcription factors that (in vertebrates) control many growth- and proliferation-associated genes, and in some contexts contribute to global gene regulation. We combine ChIPseq and RNAseq approaches in Drosophila tissue culture cells to identify a core set of less than 500 Myc target genes, whose salient function resides in the control of ribosome biogenesis. Amongst these genes we find the non-coding snoRNA genes as a large novel class of Myc targets. All assayed snoRNAs are affected by Myc, and many of them are subject to direct transcriptional activation by Myc, both in Drosophila and in vertebrates. The loss of snoRNAs impairs growth during normal development, whereas their overexpression increases tumor mass in a model for neuronal tumors. This work shows that Myc acts as a master regulator of snoRNP biogenesis. In addition, in combination with recent observations of snoRNA involvement in human cancer, it raises the possibility that Myc's transforming effects are partially mediated by this class of non-coding transcripts.

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Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 30%
Researcher 16 26%
Student > Bachelor 6 10%
Student > Master 6 10%
Student > Doctoral Student 3 5%
Other 5 8%
Unknown 7 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 33%
Agricultural and Biological Sciences 20 33%
Medicine and Dentistry 4 7%
Neuroscience 2 3%
Immunology and Microbiology 2 3%
Other 3 5%
Unknown 10 16%