Title |
Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22)
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Published in |
Molecular Cancer, April 2015
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DOI | 10.1186/s12943-015-0353-x |
Pubmed ID | |
Authors |
Hong Yao, Jinlan Pan, Chunxiao Wu, Hongjie Shen, Jundan Xie, Qinrong Wang, Lijun Wen, Qian Wang, Liang Ma, Lili Wu, Nana Ping, Yun Zhao, Aining Sun, Suning Chen |
Abstract |
RUNX1/AML1, which is a Runt family transcription factor critical for normal hematopoiesis, is frequently mutated or translocated in a broad spectrum of hematopoietic malignancies. We describe here the case of a 54-year-old female developed acute myeloid leukemia with a t(5;21)(q21;q22). Transcriptome sequencing identified the chromodomain-helicase-DNA-binding protein 1 gene, CHD1, as a novel partner gene of RUNX1. Furthermore, the patient was found to harbor FLT3-ITD mutation, which might collaborated with CHD1-RUNX1 in the development of acute myeloid leukemia. We have identified CHD1 as the RUNX1 fusion partner in acute myeloid leukemia with t(5;21)(q21;q22). |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Switzerland | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 16% |
Student > Doctoral Student | 2 | 11% |
Other | 2 | 11% |
Student > Master | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 3 | 16% |
Unknown | 5 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 32% |
Agricultural and Biological Sciences | 4 | 21% |
Medicine and Dentistry | 2 | 11% |
Immunology and Microbiology | 1 | 5% |
Chemistry | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 21% |