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Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia

Overview of attention for article published in Malaria Journal, April 2015
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Title
Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia
Published in
Malaria Journal, April 2015
DOI 10.1186/s12936-015-0625-3
Pubmed ID
Authors

Lemu Golassa, Berhanu Erko, Frederick N Baliraine, Abraham Aseffa, Göte Swedberg

Abstract

Evidence for decreasing chloroquine (CQ) efficacy against Plasmodium vivax has been reported from many endemic countries in the world. In Ethiopia, P. vivax accounts for 40% of all malaria cases and CQ is the first-line drug for vivax malaria. Mutations in multidrug resistance 1 (pvmdr-1) and K10 insertion in the pvcrt-o genes have been identified as possible molecular markers of CQ-resistance (CQR) in P. vivax. Despite reports of CQ treatment failures, no data are currently available on the prevalence of molecular markers of P. vivax resistance in Ethiopia. The objective of this study was to determine the prevalence of mutations in the pvmdr-1 and K10 insertion in the pvcrt-o genes. A total of 36 P. vivax clinical isolates were collected from West Arsi district in Ethiopia. Sequencing was used to analyse polymorphisms of the pvcrt-o and pvmdr-1 genes. Sequencing results of the pvmdr-1 fragment showed the presence of two non-synonymous mutations at positions 976 and 1076. The Y → F change at codon 976 (TAC → TTC) was observed in 21 (75%) of 28 the isolates while the F → L change (at codon 1076), which was due to a single mutation (TTT → CTT), was observed in 100% of the isolates. Of 33 samples successfully amplified for the pvcrt-o, the majority of the isolates (93.9%) were wild type, without K10 insertion. High prevalence of mutations in candidate genes conferring CQR in P. vivax was identified. The fact that CQ is still the first-line treatment for vivax malaria, the significance of mutations in the pvcrt-o and pvmdr-1 genes and the clinical response of the patients' to CQ treatment and whether thus an association exists between point mutations of the candidate genes and CQR requires further research in Ethiopia.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Burkina Faso 1 2%
Unknown 43 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 29%
Student > Master 8 18%
Student > Ph. D. Student 7 16%
Student > Postgraduate 4 9%
Student > Bachelor 3 7%
Other 5 11%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 20%
Medicine and Dentistry 8 18%
Biochemistry, Genetics and Molecular Biology 7 16%
Immunology and Microbiology 7 16%
Computer Science 3 7%
Other 4 9%
Unknown 7 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2015.
All research outputs
#10,856,309
of 14,291,367 outputs
Outputs from Malaria Journal
#3,424
of 4,125 outputs
Outputs of similar age
#144,730
of 228,287 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 14,291,367 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,125 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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