Title |
Thrombosis in vasculitis: from pathogenesis to treatment
|
---|---|
Published in |
Thrombosis Journal, April 2015
|
DOI | 10.1186/s12959-015-0047-z |
Pubmed ID | |
Authors |
Giacomo Emmi, Elena Silvestri, Danilo Squatrito, Amedeo Amedei, Elena Niccolai, Mario Milco D’Elios, Chiara Della Bella, Alessia Grassi, Matteo Becatti, Claudia Fiorillo, Lorenzo Emmi, Augusto Vaglio, Domenico Prisco |
Abstract |
In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet's syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet'syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet's syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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New Zealand | 1 | 25% |
United Kingdom | 1 | 25% |
Kuwait | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | <1% |
Unknown | 118 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 15 | 13% |
Student > Ph. D. Student | 12 | 10% |
Student > Doctoral Student | 12 | 10% |
Student > Bachelor | 12 | 10% |
Student > Postgraduate | 11 | 9% |
Other | 29 | 24% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 56 | 47% |
Immunology and Microbiology | 5 | 4% |
Nursing and Health Professions | 4 | 3% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Agricultural and Biological Sciences | 3 | 3% |
Other | 9 | 8% |
Unknown | 38 | 32% |