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Signaling by exosomal microRNAs in cancer

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, April 2015
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Title
Signaling by exosomal microRNAs in cancer
Published in
Journal of Experimental & Clinical Cancer Research, April 2015
DOI 10.1186/s13046-015-0148-3
Pubmed ID
Authors

Germana Falcone, Armando Felsani, Igea D’Agnano

Abstract

A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expression is found in almost all types of human cancer. The discovery of circulating miRNAs in body fluids and the finding that they are often tumor specific and can be detected early in tumorigenesis has soon led to the evaluation of their possible use as cancer biomarkers and treatment-response predictors. The evidence that tumor cells communicate via the secretion and delivery of miRNAs packed into tumor-released microvesicles has prompted to investigate miRNA contribution as signaling molecules to the establishment and maintenance of the tumor microenvironment and the metastatic niche in cancer. In this review we highlight the recent advances on the role of exosomal miRNAs as mediators of cancer cell-to-cell communication.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 1%
Finland 1 <1%
United States 1 <1%
Belgium 1 <1%
Unknown 149 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 21%
Researcher 24 16%
Student > Master 20 13%
Student > Bachelor 16 10%
Student > Doctoral Student 11 7%
Other 26 17%
Unknown 24 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 25%
Agricultural and Biological Sciences 33 21%
Medicine and Dentistry 31 20%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Immunology and Microbiology 5 3%
Other 11 7%
Unknown 28 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2015.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,967
of 2,378 outputs
Outputs of similar age
#240,160
of 278,627 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#17
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,378 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,627 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.