The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury

Yan Wang, Ming Ma, Qiang Tang, Luwen Zhu, Melanie Koleini, Dequan Zou

After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury. Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A , NMT-B, or NMT-C group. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed. The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups. Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.