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Histone modifications induced by MDV infection at early cytolytic and latency phases

Overview of attention for article published in BMC Genomics, April 2015
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Title
Histone modifications induced by MDV infection at early cytolytic and latency phases
Published in
BMC Genomics, April 2015
DOI 10.1186/s12864-015-1492-6
Pubmed ID
Authors

Apratim Mitra, Juan Luo, Yanghua He, Yulan Gu, Huanmin Zhang, Keji Zhao, Kairong Cui, Jiuzhou Song

Abstract

Marek's disease (MD) is a highly contagious, lymphomatous disease of chickens induced by a herpesvirus, Marek's disease virus (MDV) that is the cause of major annual losses to the poultry industry. MD pathogenesis involves multiple stages including an early cytolytic phase and latency, and transitions between these stages are governed by several host and environmental factors. The success of vaccination strategies has led to the increased virulence of MDV and selective breeding of naturally resistant chickens is seen as a viable alternative. While multiple gene expression studies have been performed in resistant and susceptible populations, little is known about the epigenetic effects of infection. In this study, we investigated temporal chromatin signatures induced by MDV by analyzing early cytolytic and latent phases of infection in the bursa of Fabricius of MD-resistant and -susceptible birds. Major global variations in chromatin marks were observed at different stages of MD in the two lines. Differential H3K27me3 marks were associated with immune-related pathways, such as MAP kinase signaling, focal adhesion and neuroactive ligand receptor interaction, and suggested varying degrees of silencing in response to infection. Immune-related microRNAs, e.g. gga-miR-155 and gga-miR-10b, bore chromatin signatures, which suggested their contribution to MD-susceptibility. Finally, several members of the focal adhesion pathway, e.g. THBS4 and ITGA1, showed marked concordance between gene expression and chromatin marks indicating putative epigenetic regulation in response to MDV infection. Our comprehensive analysis of chromatin signatures, therefore, revealed further clues about the epigenetic effects of MDV infection although further studies are necessary to elucidate the functional implications of the observed variations in histone modifications.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 19%
Student > Doctoral Student 4 15%
Student > Ph. D. Student 4 15%
Student > Bachelor 2 8%
Student > Master 2 8%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 42%
Biochemistry, Genetics and Molecular Biology 4 15%
Veterinary Science and Veterinary Medicine 3 12%
Medicine and Dentistry 2 8%
Nursing and Health Professions 1 4%
Other 1 4%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2015.
All research outputs
#14,540,771
of 24,792,414 outputs
Outputs from BMC Genomics
#5,081
of 11,067 outputs
Outputs of similar age
#130,372
of 270,447 outputs
Outputs of similar age from BMC Genomics
#123
of 269 outputs
Altmetric has tracked 24,792,414 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,067 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,447 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 269 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.