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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, September 2011
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1 tweeter

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Title
Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells
Published in
Journal of Experimental & Clinical Cancer Research, September 2011
DOI 10.1186/1756-9966-30-82
Pubmed ID
Authors

Jingyan Sun, Jinpu Yu, Hui Li, Lili Yang, Feng Wei, Wenwen Yu, Juntian Liu, Xiubao Ren

Abstract

The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in immune tolerance and promotes immune escape of IDO+ tumors. A recent hypothesis suggested that IDO may contribute to the differentiation of new T regulatory cells (Tregs) from naive CD4+ T cells. In this study we investigated the role of IDO in induction of immunosuppression in breast cancer by increasing the apoptosis of T cells and the proportion of Tregs.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Netherlands 1 3%
Korea, Republic of 1 3%
Italy 1 3%
United States 1 3%
Unknown 32 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 30%
Student > Master 7 19%
Researcher 6 16%
Student > Bachelor 3 8%
Student > Postgraduate 3 8%
Other 6 16%
Unknown 1 3%
Readers by discipline Count As %
Medicine and Dentistry 11 30%
Agricultural and Biological Sciences 10 27%
Biochemistry, Genetics and Molecular Biology 5 14%
Immunology and Microbiology 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 3 8%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2011.
All research outputs
#18,297,449
of 22,653,392 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,348
of 2,027 outputs
Outputs of similar age
#104,942
of 126,323 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#11
of 15 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,027 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,323 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.