Title |
Neuroprotection in acute brain injury: an up-to-date review
|
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Published in |
Critical Care, December 2015
|
DOI | 10.1186/s13054-015-0887-8 |
Pubmed ID | |
Authors |
Nino Stocchetti, Fabio S Taccone, Giuseppe Citerio, Paul E Pepe, Peter D Le Roux, Mauro Oddo, Kees H Polderman, Robert D Stevens, William Barsan, Andrew IR Maas, Geert Meyfroidt, Michael J Bell, Robert Silbergleit, Paul M Vespa, Alan I Faden, Raimund Helbok, Samuel Tisherman, Elisa R Zanier, Terence Valenzuela, Julia Wendon, David K Menon, Jean-Louis Vincent |
Abstract |
Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 16 | 18% |
United States | 8 | 9% |
Australia | 3 | 3% |
Malaysia | 2 | 2% |
Colombia | 1 | 1% |
Mexico | 1 | 1% |
Grenada | 1 | 1% |
Vietnam | 1 | 1% |
Sweden | 1 | 1% |
Other | 14 | 15% |
Unknown | 43 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 55 | 60% |
Practitioners (doctors, other healthcare professionals) | 25 | 27% |
Scientists | 9 | 10% |
Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 1% |
Italy | 2 | <1% |
Canada | 2 | <1% |
Brazil | 2 | <1% |
Mexico | 2 | <1% |
Japan | 2 | <1% |
Czechia | 1 | <1% |
New Zealand | 1 | <1% |
United Kingdom | 1 | <1% |
Other | 2 | <1% |
Unknown | 470 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 71 | 14% |
Researcher | 61 | 12% |
Student > Postgraduate | 54 | 11% |
Student > Bachelor | 50 | 10% |
Student > Master | 48 | 10% |
Other | 134 | 27% |
Unknown | 73 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 276 | 56% |
Neuroscience | 43 | 9% |
Agricultural and Biological Sciences | 15 | 3% |
Nursing and Health Professions | 13 | 3% |
Biochemistry, Genetics and Molecular Biology | 13 | 3% |
Other | 45 | 9% |
Unknown | 86 | 18% |