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Ketamine and transcranial magnetic stimulation treatment for bipolar II disorder: a case report

Overview of attention for article published in Journal of Medical Case Reports, March 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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Title
Ketamine and transcranial magnetic stimulation treatment for bipolar II disorder: a case report
Published in
Journal of Medical Case Reports, March 2015
DOI 10.1186/s13256-015-0520-0
Pubmed ID
Authors

Steven RD Best, Brian P Griffin, Dan G Pavel

Abstract

To the best of our knowledge, this is the first case report of successful treatment for bipolar II disorder using a combined ketamine and transcranial magnetic stimulation treatment. A 43-year-old Caucasian unemployed man presented to us with treatment-resistant bipolar II disorder, currently in a mixed state. A psychometric assessment and brain single-photon emission computer tomography scan were conducted at baseline. His psychometric assessment revealed severe depressive and manic symptoms that were consistent with bipolar II disorder. Findings from a brain single-photon emission computer tomography scan converged with those from his psychometric assessment. The combined ketamine and transcranial magnetic stimulation treatment was administered a total of 24 times over five months, with his ketamine dosage increased from 50mg at the first treatment to 600mg by the last. Starting after the second treatment, he reported substantial improvements in his symptoms. A follow-up psychometric assessment and brain single-photon emission computer tomography scan five months later revealed substantial blood flow increases in the previously deficient areas. We provide preliminary evidence for a treatment method that magnifies the therapeutic benefits of infused ketamine along with transcranial magnetic stimulation. We postulate that this may be based on an interaction at the level of the relevant cortico-thalamo-cortical circuit(s).

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The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 21%
Researcher 8 14%
Student > Ph. D. Student 5 9%
Student > Master 5 9%
Student > Doctoral Student 4 7%
Other 9 16%
Unknown 13 23%
Readers by discipline Count As %
Psychology 13 23%
Medicine and Dentistry 10 18%
Neuroscience 5 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Nursing and Health Professions 1 2%
Other 5 9%
Unknown 20 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2016.
All research outputs
#3,387,042
of 25,292,378 outputs
Outputs from Journal of Medical Case Reports
#271
of 4,514 outputs
Outputs of similar age
#41,699
of 271,551 outputs
Outputs of similar age from Journal of Medical Case Reports
#4
of 36 outputs
Altmetric has tracked 25,292,378 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,514 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,551 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.