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Factors associated with maintenance of antibody responses to influenza vaccine in older, community-dwelling adults

Overview of attention for article published in BMC Infectious Diseases, April 2015
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Title
Factors associated with maintenance of antibody responses to influenza vaccine in older, community-dwelling adults
Published in
BMC Infectious Diseases, April 2015
DOI 10.1186/s12879-015-0926-8
Pubmed ID
Authors

H Keipp Talbot, Laura A Coleman, Yuwei Zhu, Sarah Spencer, Mark Thompson, Po-Yung Cheng, Maria E Sundaram, Edward A Belongia, Marie R Griffin

Abstract

Little is known about factors associated with maintenance of hemagglutinin inhibition (HAI) antibodies after influenza vaccination in older adults. Adults ≥50 years of age were vaccinated prior to the 2009-10 influenza season. Serum was drawn pre-vaccination (S1), 21-28 days post-vaccination (S2), and after the influenza season (S3) for HAI assays. Seroconversion was defined as ≥ 4-fold increase S1 to S2 or if S1 < 10 by an S2 ≥ 40) and seroprotection was defined as S2 ≥ 40. Maintenance of antibody response was measured in participants with an S2 ≥ 40, and defined as an S3 ≥ 40. We enrolled 510 participants during Fall 2009 at Vanderbilt University Medical Center and Marshfield Clinic Research Foundation. Participants' mean age was 64 years with 62% female and 96% white. Seroconversion and seroprotection rates were lowest for influenza A H1N1 (12% and 26%, respectively), highest for influenza A H3N2 (45% and 82%), and intermediate for influenza B (28% and 72%). Of the participants with an S2 ≥ 40, 36% (46/126), 71% (289/407), and 74% (263/354) maintained an S3 ≥ 40 for H1N1, H3N2, and B influenza vaccine strains, respectively. S1 HAI titer was strongly associated with both post-vaccination seroprotection and maintaining seroprotection at S3 for all three influenza antigens. Age, sex, body mass index, self-reported stress, and vaccination site were not consistently associated with vaccine response or maintenance of response. Pre-vaccination antibody titer was the only study variable consistently and positively associated with both serologic response to vaccination and maintenance of response. Antibody responses were lowest for the H1N1 vaccine strain. CLINICALTRIALS: gov Identifier: NCT02401893.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Ph. D. Student 8 20%
Student > Master 8 20%
Student > Bachelor 4 10%
Other 2 5%
Other 4 10%
Unknown 5 13%
Readers by discipline Count As %
Medicine and Dentistry 12 30%
Agricultural and Biological Sciences 4 10%
Social Sciences 4 10%
Psychology 4 10%
Nursing and Health Professions 3 8%
Other 1 3%
Unknown 12 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2015.
All research outputs
#3,558,394
of 5,030,622 outputs
Outputs from BMC Infectious Diseases
#1,946
of 2,666 outputs
Outputs of similar age
#115,164
of 156,537 outputs
Outputs of similar age from BMC Infectious Diseases
#55
of 86 outputs
Altmetric has tracked 5,030,622 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,666 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,537 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.