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Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

Overview of attention for article published in Respiratory Research, April 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

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7 tweeters

Citations

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52 Dimensions

Readers on

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90 Mendeley
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Title
Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis
Published in
Respiratory Research, April 2018
DOI 10.1186/s12931-018-0742-y
Pubmed ID
Authors

Marlene Bloechliger, Daphne Reinau, Julia Spoendlin, Shih-Chen Chang, Klaus Kuhlbusch, Liam G. Heaney, Susan S. Jick, Christoph R. Meier

Abstract

To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK. Using data from the UK-based Clinical Practice Research Datalink, we conducted a series of cohort studies to quantify incidence rates and incidence rate ratios, and a series of nested case-control analyses to estimate crude and adjusted odds ratios, of 11 different potential corticosteroid-related adverse events (bone-related conditions, hypertension, peptic ulcer, severe infections, herpes zoster, diabetes mellitus type 2, cataract, glaucoma, chronic kidney disease, affective disorders, and cardiovascular events). Between 165,900 and 269,368 asthma patients were included in each of the 11 cohorts, of whom between 836 and 16,192 developed an outcome of interest. Incidence rates per 1000 person-years of potential corticosteroid-related adverse events in patients with new current use of oral prednisolone ranged from 1.4 (95% confidence interval [CI], 1.0-1.8) for peptic ulcer to 78.0 (95% CI, 74.8-81.2) for severe infections. After adjusting for confounding, current oral prednisolone use was most strongly associated with an increased risk of severe infection, compared with non-use of prednisolone; OR 2.16 (95% CI, 2.05-2.27). There were smaller elevated risks of peptic ulcer, affective disorders, and cataract at higher doses, and marginally increased risks of herpes zoster, cardiovascular events, diabetes mellitus type 2, and bone related conditions, compared with non-use of prednisolone. We did not observe an association between oral prednisolone use and glaucoma, chronic kidney disease, or hypertension. Oral prednisolone use is associated with infections, gastrointestinal, neuropsychiatric, ocular, cardiovascular, metabolic, and bone-related complications among adult asthma patients.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 90 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 16%
Student > Ph. D. Student 13 14%
Student > Master 10 11%
Other 9 10%
Student > Bachelor 7 8%
Other 14 16%
Unknown 23 26%
Readers by discipline Count As %
Medicine and Dentistry 30 33%
Pharmacology, Toxicology and Pharmaceutical Science 12 13%
Biochemistry, Genetics and Molecular Biology 4 4%
Psychology 4 4%
Economics, Econometrics and Finance 3 3%
Other 10 11%
Unknown 27 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2018.
All research outputs
#4,625,520
of 14,995,047 outputs
Outputs from Respiratory Research
#616
of 1,864 outputs
Outputs of similar age
#104,944
of 276,068 outputs
Outputs of similar age from Respiratory Research
#1
of 2 outputs
Altmetric has tracked 14,995,047 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,864 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them