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MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance

Overview of attention for article published in European Journal of Medical Research, April 2015
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Title
MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance
Published in
European Journal of Medical Research, April 2015
DOI 10.1186/s40001-015-0139-z
Pubmed ID
Authors

Dong Lan, Xin Zhang, Rongquan He, Ruixue Tang, Ping Li, Qiancheng He, Gang Chen

Abstract

Despite present studies which suggested miR-133a as a promising biomarker for several cancers, there still exist no articles concerning the validated clinical significance of miR-133a in non-small cell lung cancer (NSCLC). Therefore, in this study, we targeted the correlation between miR-133a expression and clinicopathological significance in NSCLC patients. The expression of miR-133a in 125 cases of NSCLC and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Meanwhile, the relationship between miR-133a expression and several clinicopathological parameters and patient survival was analyzed. The relative level of miR-133a was 2.0108 ± 1.3334 in NSCLC tissues, significantly lower than that of the adjacent non-cancerous lung tissues (3.6430 ± 2.2625, P = 0.019). The area under curve (AUC) of low expression of miR-133a to diagnose NSCLC was 0.760 (95% CI: 0.702 ~ 0.819, P < 0.001). MiR-133a expression was negatively correlated to lymphatic metastasis (r = -0.182, P = 0.042), tumor size (r = -0.253, P = 0.04), clinical TNM stages (r = -0.154, P = 0.087), and EGFR protein expression (r = -0.612, P < 0.001). MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Ph. D. Student 4 17%
Student > Bachelor 3 13%
Professor 1 4%
Student > Master 1 4%
Other 1 4%
Unknown 8 35%
Readers by discipline Count As %
Medicine and Dentistry 7 30%
Agricultural and Biological Sciences 4 17%
Biochemistry, Genetics and Molecular Biology 3 13%
Unknown 9 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2015.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from European Journal of Medical Research
#728
of 923 outputs
Outputs of similar age
#240,425
of 279,915 outputs
Outputs of similar age from European Journal of Medical Research
#14
of 21 outputs
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.