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Some aspects of interactivity between endocrine and immune systems required for successful reproduction

Overview of attention for article published in Reproductive Biology and Endocrinology, April 2015
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21 Mendeley
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Title
Some aspects of interactivity between endocrine and immune systems required for successful reproduction
Published in
Reproductive Biology and Endocrinology, April 2015
DOI 10.1186/s12958-015-0020-5
Pubmed ID
Authors

Andrea Weghofer, Eric Himaya, Vitaly A Kushnir, David H Barad, Emanuela Lazzaroni-Tealdi, Yao Yu, Yan-Guang Wu, Norbert Gleicher

Abstract

In successful reproduction, endocrine and immune systems closely interact. We here attempt to further elucidate the relationship between androgen levels, systemic activation of the immune system and reproductive success in infertile women, utilizing 2 distinct infertile patient cohorts. In Group 1, we investigated 322 women (ages 38.6 +/- 5.4 years) at initial presentation; in Group 2 125 women undergoing in vitro fertilization (169 IVF cycles, ages 38.9 +/- 5.5 years). In Group 1, we assessed androgens and an immune panel, previously demonstrated to discriminate between activated quiescent immune systems; in Group 2, utilizing the same immune panel, we investigated whether immune system activation relates to embryo quality in IVF cycles. No individual immune test within the immune panel was associated with androgen levels. The total/free testosterone ratio (TT/FT) was, however, significantly associated with presence of gammopathies (in IgG, IgM, IgA, IgE; P = 0.026). Surprisingly, immune system activation was associated with significantly improved embryo quality (P = 0.008), a finding persistent after adjustment for age and repeat IVF cycles (P = 0.006). Association of immune system activation with improved embryo quality concurs with previously reported immune activation in association with normal functional ovarian reserve (FOR) and normal androgen levels, while, counter intuitively, hypoandrogenism and low FOR are associated with lack of immune system activation. Mild immune system activation, therefore, likely appears essential for establishment of pregnancy, and may be regulated by androgens.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 3 14%
Student > Bachelor 3 14%
Student > Master 3 14%
Researcher 2 10%
Student > Doctoral Student 1 5%
Other 3 14%
Unknown 6 29%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Agricultural and Biological Sciences 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Immunology and Microbiology 2 10%
Nursing and Health Professions 1 5%
Other 1 5%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2015.
All research outputs
#14,222,419
of 22,800,560 outputs
Outputs from Reproductive Biology and Endocrinology
#459
of 973 outputs
Outputs of similar age
#139,466
of 264,711 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#13
of 23 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 973 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.