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Molecular characterization and targeted therapeutic approaches in breast cancer

Overview of attention for article published in Breast Cancer Research, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

twitter
7 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
119 Dimensions

Readers on

mendeley
270 Mendeley
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Title
Molecular characterization and targeted therapeutic approaches in breast cancer
Published in
Breast Cancer Research, April 2015
DOI 10.1186/s13058-015-0560-9
Pubmed ID
Authors

Angela Toss, Massimo Cristofanilli

Abstract

Despite the wide improvements in breast cancer (BC) detection and adjuvant treatment, BC is still responsible for approximately 40,000 deaths annually in the United States. Novel biomarkers are fundamental to assist clinicians in BC detection, risk stratification, disease subtyping, prediction of treatment response, and surveillance, allowing a more tailored approach to therapy in both primary and metastatic settings. In primary BC, the development of molecular profiling techniques has added prognostic and predictive information to conventional biomarkers - estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Moreover, the application of next-generation sequencing and reverse-phase protein microarray methods in the metastatic setting holds the promise to further advance toward a personalized management of cancer. The improvement in our understanding on BC biology associated with the study of the genomic aberrations characterizing the most common molecular subtypes allows us to explore new targets for drug development. Finally, the integration of cancer stem cell-targeted therapies and immune therapies in future combination regimens increases our chances to successfully treat a larger proportion of women with more aggressive and resistant metastatic disease. This article reviews the current state of novel biological markers for BC, the evidence to demonstrate their clinical validity and utility, and the implication for therapeutic targeting.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
United States 1 <1%
Netherlands 1 <1%
Canada 1 <1%
Unknown 266 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 46 17%
Student > Ph. D. Student 45 17%
Student > Bachelor 31 11%
Researcher 27 10%
Student > Doctoral Student 18 7%
Other 49 18%
Unknown 54 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 69 26%
Medicine and Dentistry 63 23%
Agricultural and Biological Sciences 33 12%
Pharmacology, Toxicology and Pharmaceutical Science 14 5%
Nursing and Health Professions 7 3%
Other 19 7%
Unknown 65 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2019.
All research outputs
#3,553,452
of 20,089,504 outputs
Outputs from Breast Cancer Research
#451
of 1,807 outputs
Outputs of similar age
#47,302
of 241,698 outputs
Outputs of similar age from Breast Cancer Research
#1
of 1 outputs
Altmetric has tracked 20,089,504 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,807 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them