Title |
Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study
|
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Published in |
Critical Care, December 2015
|
DOI | 10.1186/s13054-015-0937-2 |
Pubmed ID | |
Authors |
Luuk Wieske, Daniela S Dettling-Ihnenfeldt, Camiel Verhamme, Frans Nollet, Ivo N van Schaik, Marcus J Schultz, Janneke Horn, Marike van der Schaaf |
Abstract |
Intensive Care Unit - acquired weakness (ICU-AW) is thought to mediate physical impairments in survivors of critical illness but few studies have investigated this thoroughly. The purpose was to investigate differences in post-ICU mortality and physical functioning between patients with and without ICU-AW at 6 months after ICU discharge. ICU patients, mechanically ventilated ≥2 days, were included in a single center prospective observational cohort study. ICU-AW was diagnosed when the average Medical Research Council (MRC) score was <4 in awake and attentive patients. Post-ICU mortality was recorded until 6 months after ICU discharge; in surviving patients physical functioning was assessed using the Short-Form Health Survey (SF-36) physical functioning (PF) domain. The independent effect of ICU-AW on post-ICU mortality was analyzed using a multivariable Cox proportional hazards model. The independent effect of ICU-AW on the PF domain score was analyzed using a multivariable linear regression model. 156 patients were included, of whom 80 with ICU-AW. Twenty-three patients died in the ICU (20 with ICU-AW); during the 6 months follow-up after ICU discharge another 25 patients died (17 with ICU-AW). PF scores were available for 96 survivors (39 patients with ICU-AW). ICU-AW was independently associated with an increase in post-ICU mortality (HR 3.6 (95% CI: 1.3 to 9.8); p:0.01) and with a decrease in physical functioning (β: -16.7 points (95% CI: -30.2 to -3.1); p:0.02). ICU-AW is independently associated with higher post-ICU mortality and with clinically relevant lower physical functioning in survivors at 6 months after ICU discharge. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 20% |
Australia | 3 | 15% |
Spain | 2 | 10% |
Puerto Rico | 2 | 10% |
Colombia | 1 | 5% |
United Kingdom | 1 | 5% |
Canada | 1 | 5% |
Unknown | 6 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 45% |
Scientists | 5 | 25% |
Science communicators (journalists, bloggers, editors) | 3 | 15% |
Practitioners (doctors, other healthcare professionals) | 3 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | <1% |
Netherlands | 1 | <1% |
Switzerland | 1 | <1% |
Ecuador | 1 | <1% |
Chile | 1 | <1% |
Unknown | 292 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 45 | 15% |
Student > Bachelor | 35 | 12% |
Student > Ph. D. Student | 27 | 9% |
Student > Doctoral Student | 26 | 9% |
Student > Postgraduate | 25 | 8% |
Other | 67 | 22% |
Unknown | 73 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 103 | 35% |
Nursing and Health Professions | 65 | 22% |
Neuroscience | 9 | 3% |
Sports and Recreations | 6 | 2% |
Agricultural and Biological Sciences | 4 | 1% |
Other | 25 | 8% |
Unknown | 86 | 29% |