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Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

Overview of attention for article published in Malaria Journal, April 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

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5 news outlets
policy
1 policy source
twitter
2 X users

Citations

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60 Dimensions

Readers on

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115 Mendeley
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Title
Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya
Published in
Malaria Journal, April 2015
DOI 10.1186/s12936-015-0671-x
Pubmed ID
Authors

Susanne H Hodgson, Elizabeth Juma, Amina Salim, Charles Magiri, Daniel Njenga, Sassy Molyneux, Patricia Njuguna, Ken Awuondo, Brett Lowe, Peter F Billingsley, Andrew O Cole, Caroline Ogwang, Faith Osier, Roma Chilengi, Stephen L Hoffman, Simon J Draper, Bernhards Ogutu, Kevin Marsh

Abstract

Controlled human malaria infection (CHMI) studies, in which healthy volunteers are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines and drugs, have become a vital tool to accelerate vaccine and drug development. CHMI studies provide a cost-effective and expeditious way to circumvent the use of large-scale field efficacy studies to deselect intervention candidates. However, to date few modern CHMI studies have been performed in malaria-endemic countries. An open-label, randomized pilot CHMI study was conducted using aseptic, purified, cryopreserved, infectious P. falciparum sporozoites (SPZ) (Sanaria® PfSPZ Challenge) administered intramuscularly (IM) to healthy Kenyan adults (n = 28) with varying degrees of prior exposure to P. falciparum. The purpose of the study was to establish the PfSPZ Challenge CHMI model in a Kenyan setting with the aim of increasing the international capacity for efficacy testing of malaria vaccines and drugs, and allowing earlier assessment of efficacy in a population for which interventions are being developed. This was part of the EDCTP-funded capacity development of the CHMI platform in Africa. This paper discusses in detail lessons learnt from conducting the first CHMI study in Kenya. Issues pertinent to the African setting, including community sensitization, consent and recruitment are considered. Detailed reasoning regarding the study design (for example, dose and route of administration of PfSPZ Challenge, criteria for grouping volunteers according to prior exposure to malaria and duration of follow-up post CHMI) are given and changes other centres may want to consider for future studies are suggested. Performing CHMI studies in an African setting presents unique but surmountable challenges and offers great opportunity for acceleration of malaria vaccine and drug development. The reflections in this paper aim to aid other centres and partners intending to use the CHMI model in Africa.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 2 2%
United Kingdom 1 <1%
Ghana 1 <1%
Unknown 111 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 21%
Student > Ph. D. Student 20 17%
Researcher 14 12%
Student > Bachelor 6 5%
Student > Doctoral Student 5 4%
Other 17 15%
Unknown 29 25%
Readers by discipline Count As %
Medicine and Dentistry 27 23%
Immunology and Microbiology 11 10%
Agricultural and Biological Sciences 10 9%
Nursing and Health Professions 8 7%
Biochemistry, Genetics and Molecular Biology 6 5%
Other 21 18%
Unknown 32 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2022.
All research outputs
#941,851
of 24,400,706 outputs
Outputs from Malaria Journal
#123
of 5,827 outputs
Outputs of similar age
#11,750
of 268,810 outputs
Outputs of similar age from Malaria Journal
#6
of 119 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.