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The promise of stem cells in the therapy of Alzheimer’s disease

Overview of attention for article published in Translational Neurodegeneration, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
42 Mendeley
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Title
The promise of stem cells in the therapy of Alzheimer’s disease
Published in
Translational Neurodegeneration, April 2015
DOI 10.1186/s40035-015-0029-x
Pubmed ID
Authors

Chunmei Yue, Naihe Jing

Abstract

Alzheimer's disease (AD), a common neurodegenerative disorder associated with gradually to dramatic neuronal death, synaptic loss and dementia, is considered to be one of the most obscure and intractable brain disorders in medicine. Currently, there is no therapy clinically available to induce marked symptomatic relief in AD patients. In recent years, the proof-of-concept studies using stem cell-based approaches in transgenic AD animal models provide new hope to develop stem cell-based therapies for the effective treatment of AD. The degeneration of basal forebrain cholinergic neurons (BFCNs) and the resultant cholinergic abnormalities in the brain contribute substantially to the cognitive decline of AD patients. The approches using stem cell-derived BFCNs as donor cells need to be developed, and to provide proof of principle that this subtype-specific neurons can induce functional recovery of AD animal models. With the continuous scientific advances in both academic and industrial fields, the potentials of stem cells in cellular neuroprotection and cell replacement in vivo have been elucidated, and stem cell-based therapy for repairing degenerative brains of AD is promising.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Poland 1 2%
Germany 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 36%
Researcher 7 17%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 4 10%
Student > Bachelor 3 7%
Other 6 14%
Unknown 2 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 24%
Medicine and Dentistry 8 19%
Neuroscience 6 14%
Agricultural and Biological Sciences 5 12%
Psychology 4 10%
Other 3 7%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2015.
All research outputs
#2,225,526
of 19,208,681 outputs
Outputs from Translational Neurodegeneration
#65
of 247 outputs
Outputs of similar age
#33,112
of 239,864 outputs
Outputs of similar age from Translational Neurodegeneration
#1
of 1 outputs
Altmetric has tracked 19,208,681 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 247 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,864 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them