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Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis

Overview of attention for article published in Military Medical Research, April 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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7 X users

Citations

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21 Dimensions

Readers on

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40 Mendeley
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Title
Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis
Published in
Military Medical Research, April 2018
DOI 10.1186/s40779-018-0160-y
Pubmed ID
Authors

Ying Wang, Ya Huang, Jing Yang, Fang-Qiang Zhou, Lian Zhao, Hong Zhou

Abstract

Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful. This paper reviewed data regarding lactic acidosis treatment and recommended that pyruvate might be a potential alkalizer to correct type A lactic acidosis in future clinical practice. Pyruvate is a key energy metabolic substrate and a pyruvate dehydrogenase (PDH) activator with several unique beneficial biological properties, including anti-oxidant and anti-inflammatory effects and the ability to activate the hypoxia-inducible factor-1 (HIF-1α) - erythropoietin (EPO) signal pathway. Pyruvate preserves glucose metabolism and cellular energetics better than bicarbonate, lactate, acetate and malate in the efficient correction of hypoxic lactic acidosis and shows few side effects. Therefore, application of pyruvate may be promising and safe as a novel therapeutic strategy in hypoxic lactic acidosis correction accompanied with multi-organ protection in critical care patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Doctoral Student 4 10%
Student > Bachelor 3 8%
Student > Ph. D. Student 3 8%
Student > Master 3 8%
Other 5 13%
Unknown 15 38%
Readers by discipline Count As %
Medicine and Dentistry 7 18%
Sports and Recreations 3 8%
Neuroscience 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Philosophy 1 3%
Other 7 18%
Unknown 18 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2024.
All research outputs
#8,579,754
of 25,483,400 outputs
Outputs from Military Medical Research
#121
of 443 outputs
Outputs of similar age
#138,132
of 340,054 outputs
Outputs of similar age from Military Medical Research
#5
of 11 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 443 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.