Title |
Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time
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Published in |
Veterinary Research, May 2015
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DOI | 10.1186/s13567-015-0179-y |
Pubmed ID | |
Authors |
Ben C Maddison, John Spiropoulos, Christopher M Vickery, Richard Lockey, Jonathan P Owen, Keith Bishop, Claire A Baker, Kevin C Gough |
Abstract |
Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrP(Sc) phenotypes were present: G338 or Apl338ii. Thirteen months later some divergent PrP(Sc) phenotypes were seen: a mixture of Apl338ii with either G338 or P338, and a completely novel PrP(Sc) deposition, designated Cag338. The data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant PrP(Sc) biological/biochemical properties. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 25% |
Student > Ph. D. Student | 3 | 25% |
Other | 2 | 17% |
Professor | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 33% |
Agricultural and Biological Sciences | 3 | 25% |
Environmental Science | 2 | 17% |
Veterinary Science and Veterinary Medicine | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Other | 0 | 0% |
Unknown | 1 | 8% |