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Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs

Overview of attention for article published in Veterinary Research, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

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6 tweeters

Citations

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43 Dimensions

Readers on

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63 Mendeley
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Title
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs
Published in
Veterinary Research, May 2015
DOI 10.1186/s13567-015-0180-5
Pubmed ID
Authors

Kimberly Crawford, Kelly Lager, Laura Miller, Tanja Opriessnig, Priscilla Gerber, Richard Hesse

Abstract

Clinical disease associated with porcine epidemic diarrhea virus (PEDV) infection in naïve pigs is well chronicled; however, information on endemic PEDV infection is limited. To characterize chronic PEDV infection, the duration of infectious virus shedding and development of protective immunity was determined. On Day 0 (D0), a growing pig was challenged with PEDV and 13 contacts were commingled. On D7, 9 contact pigs (principal virus group (PG)), were selected, moved to a separate room and commingled with one sentinel pig (S1). This process was repeated weekly with S2, S3 and S4. The PG was PEDV-positive by PCR from D3-11, with some pigs intermittently positive to D42. Pigs S1 and S2 were PEDV-positive within 24 hours of commingling. Antibodies were detected in all PG by D21 and by 7 days post-contact in S1 and S2. Pigs S3 and S4 were PCR and antibody negative following commingling. To evaluate protective immunity, 5 naïve pigs (N) and the PG were challenged (N/C, PG/C) with homologous virus on D49. All N/C pigs were PEDV PCR-positive by D52 with detection out to D62 in 3/5 N/C pigs. All PG/C pigs were PEDV PCR-negative post-challenge. By D63, all N/C seroconverted. Although PEDV RNA was demonstrated in pigs after primary infection until D42, infectious PEDV capable of horizontal transmission to naïve pigs was only shed 14-16 days after infection to age-matched pigs. Homologous re-challenge 49 days post initial PEDV exposure did not result in re-infection of the pigs. This demonstrates potential for an effective PEDV vaccine.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 24%
Student > Master 15 24%
Student > Ph. D. Student 9 14%
Student > Bachelor 7 11%
Student > Doctoral Student 3 5%
Other 6 10%
Unknown 8 13%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 18 29%
Agricultural and Biological Sciences 17 27%
Medicine and Dentistry 7 11%
Biochemistry, Genetics and Molecular Biology 6 10%
Mathematics 2 3%
Other 6 10%
Unknown 7 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2021.
All research outputs
#6,785,478
of 21,078,563 outputs
Outputs from Veterinary Research
#333
of 1,128 outputs
Outputs of similar age
#82,516
of 244,400 outputs
Outputs of similar age from Veterinary Research
#1
of 1 outputs
Altmetric has tracked 21,078,563 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,128 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them