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Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney…

Overview of attention for article published in Critical Care, December 2015
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Title
Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0941-6
Pubmed ID
Authors

Xingui Dai, Zhenhua Zeng, Chunlai Fu, Sheng’an Zhang, Yeping Cai, Zhongqing Chen

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL), cystatin (Cys)-C, and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are novel diagnostic biomarkers of acute kidney injury (AKI). We aimed to determine the diagnostic properties of these biomarkers for detecting AKI in critically ill patients with sepsis. We divided 112 septic patients into the non-AKI sepsis (n = 57) and AKI sepsis (n = 55) group. Plasma and urine specimens were collected on admission and every 24 h until 72 h and tested for NGAL, Cys-C, and TREM-1 concentrations. Their levels were compared on admission, at diagnosis and 24 h before diagnosis. Both plasma and urine NGAL, Cys-C and sTREM-1 were significantly associated with AKI development in septic patients, even after adjustment for confounders using generalized estimating equations (GEEs). Compared with the non-AKI sepsis group, the sepsis AKI group exhibited markedly higher levels of these biomarkers at diagnosis and 24 h before AKI diagnosis (P < 0.01). The diagnostic and predictive values of plasma and urine NGAL were good, and those of plasma and urine Cys-C and sTREM-1 were fair. Plasma and urine NGAL, Cys-C, and sTREM-1 can be used as diagnostic and predictive biomarkers for AKI in critically ill patients with sepsis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Brazil 1 1%
Unknown 91 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 13 14%
Student > Ph. D. Student 10 11%
Researcher 10 11%
Student > Bachelor 9 10%
Student > Master 7 8%
Other 15 16%
Unknown 29 31%
Readers by discipline Count As %
Medicine and Dentistry 43 46%
Agricultural and Biological Sciences 5 5%
Nursing and Health Professions 3 3%
Biochemistry, Genetics and Molecular Biology 3 3%
Veterinary Science and Veterinary Medicine 2 2%
Other 10 11%
Unknown 27 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2015.
All research outputs
#16,721,208
of 25,373,627 outputs
Outputs from Critical Care
#5,380
of 6,554 outputs
Outputs of similar age
#228,282
of 395,408 outputs
Outputs of similar age from Critical Care
#452
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,408 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.