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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
|
|---|---|
| Published in |
Retrovirology, May 2015
|
| DOI | 10.1186/s12977-015-0160-x |
| Pubmed ID | |
| Authors |
Maria Pino, Itziar Erkizia, Susana Benet, Elina Erikson, Maria Teresa Fernández-Figueras, Dolores Guerrero, Judith Dalmau, Dan Ouchi, Antonio Rausell, Angela Ciuffi, Oliver T Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado, Nuria Izquierdo-Useros |
| Abstract |
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| Spain | 1 | 7% |
| Venezuela, Bolivarian Republic of | 1 | 7% |
| United Kingdom | 1 | 7% |
| Unknown | 7 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 86% |
| Science communicators (journalists, bloggers, editors) | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| Unknown | 94 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 22% |
| Researcher | 13 | 14% |
| Student > Master | 13 | 14% |
| Student > Bachelor | 10 | 10% |
| Professor > Associate Professor | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 25 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 22% |
| Immunology and Microbiology | 21 | 22% |
| Biochemistry, Genetics and Molecular Biology | 13 | 14% |
| Medicine and Dentistry | 11 | 11% |
| Engineering | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2020.
All research outputs
#1,220,511
of 25,613,746 outputs
Outputs from Retrovirology
#43
of 1,274 outputs
Outputs of similar age
#14,847
of 279,718 outputs
Outputs of similar age from Retrovirology
#4
of 25 outputs
Altmetric has tracked 25,613,746 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.