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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Concordant and discordant DNA methylation signatures of aging in human blood and brain
|
|---|---|
| Published in |
Epigenetics & Chromatin, May 2015
|
| DOI | 10.1186/s13072-015-0011-y |
| Pubmed ID | |
| Authors |
Pau Farré, Meaghan J Jones, Michael J Meaney, Eldon Emberly, Gustavo Turecki, Michael S Kobor |
| Abstract |
DNA methylation is an epigenetic mark that balances plasticity with stability. While DNA methylation exhibits tissue specificity, it can also vary with age and potentially environmental exposures. In studies of DNA methylation, samples from specific tissues, especially brain, are frequently limited and so surrogate tissues are often used. As yet, we do not fully understand how DNA methylation profiles of these surrogate tissues relate to the profiles of the central tissue of interest. We have adapted principal component analysis to analyze data from the Illumina 450K Human Methylation array using a set of 17 individuals with 3 brain regions and whole blood. All of the top five principal components in our analysis were associated with a variable of interest: principal component 1 (PC1) differentiated brain from blood, PCs 2 and 3 were representative of tissue composition within brain and blood, respectively, and PCs 4 and 5 were associated with age of the individual (PC4 in brain and PC5 in both brain and blood). We validated our age-related PCs in four independent sample sets, including additional brain and blood samples and liver and buccal cells. Gene ontology analysis of all five PCs showed enrichment for processes that inform on the functions of each PC. Principal component analysis (PCA) allows simultaneous and independent analysis of tissue composition and other phenotypes of interest. We discovered an epigenetic signature of age that is not associated with cell type composition and required no correction for cellular heterogeneity. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 18% |
| Canada | 4 | 14% |
| United Kingdom | 2 | 7% |
| Belgium | 1 | 4% |
| Italy | 1 | 4% |
| India | 1 | 4% |
| France | 1 | 4% |
| Unknown | 13 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 71% |
| Scientists | 6 | 21% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 142 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 20% |
| Student > Ph. D. Student | 26 | 18% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Other | 27 | 19% |
| Unknown | 27 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 23% |
| Agricultural and Biological Sciences | 32 | 22% |
| Neuroscience | 12 | 8% |
| Medicine and Dentistry | 10 | 7% |
| Psychology | 7 | 5% |
| Other | 15 | 10% |
| Unknown | 35 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2024.
All research outputs
#1,512,965
of 25,608,265 outputs
Outputs from Epigenetics & Chromatin
#19
of 616 outputs
Outputs of similar age
#18,576
of 279,272 outputs
Outputs of similar age from Epigenetics & Chromatin
#2
of 10 outputs
Altmetric has tracked 25,608,265 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 616 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,272 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.