Title |
HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients
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Published in |
Arthritis Research & Therapy, October 2011
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DOI | 10.1186/ar3479 |
Pubmed ID | |
Authors |
Pieter WA Meyer, Bridget Hodkinson, Mahmood Ally, Eustasius Musenge, Ahmed A Wadee, Heidi Fickl, Mohammed Tikly, Ronald Anderson |
Abstract |
The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE subtypes on the basis of the American College of Rheumatology 1987 revised criteria for the classification of RA in a cohort of South African RA patients (n = 143) and their association with clinical and circulating biomarkers of disease activity (autoantibodies, acute phase reactants and cytokines). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Paraguay | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Doctoral Student | 3 | 13% |
Professor | 3 | 13% |
Researcher | 2 | 8% |
Other | 5 | 21% |
Unknown | 4 | 17% |
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Medicine and Dentistry | 7 | 29% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Agricultural and Biological Sciences | 4 | 17% |
Immunology and Microbiology | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 21% |