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The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult-onset still’s disease

Overview of attention for article published in BMC Musculoskeletal Disorders, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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1 policy source
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2 tweeters

Citations

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20 Dimensions

Readers on

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27 Mendeley
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Title
The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult-onset still’s disease
Published in
BMC Musculoskeletal Disorders, May 2015
DOI 10.1186/s12891-015-0569-3
Pubmed ID
Authors

Der-Yuan Chen, Yi-Ming Chen, Chi-Chen Lin, Chia-Wei Hsieh, Yen-Ching Wu, Wei-Ting Hung, Hsin-Hua Chen, Joung-Liang Lan

Abstract

Accumulating evidence has demonstrated a pathogenic role of advanced glycation end products (AGEs) and receptors for AGEs (RAGE) in inflammation. Soluble RAGE (sRAGE), with the same ligands-binding capacity as full-length RAGE, acts as a "decoy" receptor. However, there has been scanty data regarding AGEs and sRAGE in adult-onset Still's disease (AOSD). This study aimed to investigate AGEs and sRAGE levels in AOSD patients and examine their association with clinical characteristics. Using ELISA, plasma levels of AGEs and sRAGE were determined in 52 AOSD patients, 36 systemic lupus erythematosus(SLE) patients and 16 healthy controls(HC). Their associations with activity parameters and disease courses were evaluated. Significantly higher median levels of AGEs were observed in active AOSD patients (16.75 pg/ml) and active SLE patients (14.80 pg/ml) than those in HC (9.80 pg/ml, both p < 0.001). AGEs levels were positively correlated with activity scores (r = 0.836, p < 0.001), ferritin levels (r = 0.372, p < 0.05) and CRP levels (r = 0.396, p < 0.005) in AOSD patients. Conversely, significantly lower median levels of sRAGE were observed in active AOSD patients (632.2 pg/ml) and active SLE patients (771.6 pg/ml) compared with HC (1051.7 pg/ml, both p < 0.001). Plasma sRAGE levels were negatively correlated with AOSD activity scores (r = -0.320, p < 0.05). In comparison to AOSD patients with monocyclic pattern, significantly higher AGEs levels were observed in those with polycyclic or chronic articular pattern. With treatment, AGEs levels declined while sRAGE levels increased in parallel with the decrease in disease activity. The elevation of AGEs levels with concomitant decreased sRAGE levels in active AOSD patients, suggests their pathogenic role in AOSD.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Belgium 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Researcher 3 11%
Other 2 7%
Lecturer 2 7%
Student > Doctoral Student 2 7%
Other 6 22%
Unknown 6 22%
Readers by discipline Count As %
Medicine and Dentistry 7 26%
Biochemistry, Genetics and Molecular Biology 5 19%
Agricultural and Biological Sciences 2 7%
Immunology and Microbiology 2 7%
Computer Science 1 4%
Other 5 19%
Unknown 5 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2022.
All research outputs
#6,179,070
of 22,046,823 outputs
Outputs from BMC Musculoskeletal Disorders
#1,206
of 3,930 outputs
Outputs of similar age
#70,899
of 246,745 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#1
of 1 outputs
Altmetric has tracked 22,046,823 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,930 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them