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Central venous-to-arterial carbon dioxide difference as a prognostic tool in high-risk surgical patients

Overview of attention for article published in Critical Care, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

20 tweeters
1 Facebook page
1 Google+ user


47 Dimensions

Readers on

95 Mendeley
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Central venous-to-arterial carbon dioxide difference as a prognostic tool in high-risk surgical patients
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0917-6
Pubmed ID

Emmanuel Robin, Emmanuel Futier, Oscar Pires, Maher Fleyfel, Benoit Tavernier, Gilles Lebuffe, Benoit Vallet


The purpose of this study was to evaluate the clinical relevance of high values of central venous-to-arterial carbon dioxide difference (PCO2 gap) in high risk surgical patients admitted in postoperative intensive care unit (ICU). We hypothesized that PCO2 gap could serve as a useful tool to identify patients still requiring hemodynamic optimization at ICU admission. 115 patients were included in this prospective single centre observational study during a one year period. High risk surgical inclusion criteria were adapted from Schoemaker et al. Demographic and biological data, PCO2 gap, ScvO2, lactate level and postoperative complications were recorded for all patients at ICU admission, 6 hours and 12 hours after admission. A total of 78 (68%) patients developed postoperative complications whom 54 (47%) developed organ failure. From H0 to H12, there was a significant difference for mean PCO2 gap (8.7 ± 2.8 mmHg vs 5.1 ± 2.6 mmHg; p = 0.001) and median lactate values (1.54[1.1-3.2] mmol.l(-1) vs 1.06 ± [0.8-1.8] mmol.l(-1); p = 0.003) between patients who developed postoperative complications and those who did not. These differences were maximal at admission in ICU. At ICU admission, area under the receiver operating characteristic curve for occurrence of postoperative complications was 0.86 for the PCO2 gap compared to SOFA score (0.82), SAPS II score (0.67), lactate level (0.67). Threshold value for PCO2 gap was 5.8 mmHg. Multivariate analysis showed that only high PCO2 gap and a high SOFA score were independently associated with the occurrence of postoperative complications. A high PCO2 gap (≥6 mmHg) was associated to more organ failure, an increase in duration of mechanical ventilation and length of hospital stay. A high PCO2 gap at admission in postoperative ICU was significantly associated with increased postoperative complications in high risk surgical patients. If the increase in PCO2 gap is secondary to tissue hypoperfusion then the PCO2 gap might be a useful tool complementary to ScvO2 as therapeutic target.

Twitter Demographics

The data shown below were collected from the profiles of 20 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Czechia 1 1%
Egypt 1 1%
Mexico 1 1%
Denmark 1 1%
United States 1 1%
Unknown 89 94%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 14 15%
Student > Master 14 15%
Other 10 11%
Student > Ph. D. Student 8 8%
Student > Doctoral Student 7 7%
Other 25 26%
Unknown 17 18%
Readers by discipline Count As %
Medicine and Dentistry 64 67%
Biochemistry, Genetics and Molecular Biology 2 2%
Unspecified 2 2%
Neuroscience 2 2%
Agricultural and Biological Sciences 1 1%
Other 3 3%
Unknown 21 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2016.
All research outputs
of 15,641,217 outputs
Outputs from Critical Care
of 4,941 outputs
Outputs of similar age
of 232,934 outputs
Outputs of similar age from Critical Care
of 6 outputs
Altmetric has tracked 15,641,217 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,941 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,934 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them