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Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder

Overview of attention for article published in Molecular Autism, May 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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4 news outlets
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4 blogs
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4 Facebook pages

Citations

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71 Dimensions

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156 Mendeley
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Title
Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder
Published in
Molecular Autism, May 2015
DOI 10.1186/s13229-015-0005-4
Pubmed ID
Authors

Christine Wu Nordahl, Ana-Maria Iosif, Gregory S Young, Lee Michael Perry, Robert Dougherty, Aaron Lee, Deana Li, Michael H Buonocore, Tony Simon, Sally Rogers, Brian Wandell, David G Amaral

Abstract

Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. Structural and diffusion-weighted images were acquired in 139 preschool-aged children with ASD (112 males/27 females) and 82 typically developing (TD) controls (53 males/29 females). Longitudinal scanning at two additional annual time points was carried out in a subset of these participants. Callosal organization was evaluated using two approaches: 1) diffusion tensor imaging (DTI) tractography to define subregions based on cortical projection zones and 2) as a comparison to previous studies, midsagittal area analysis using Witelson subdivisions. Diffusion measures of callosal fibers were also evaluated. Analyses of cortical projection zone subregions revealed sex differences in the patterns of altered callosal organization. Relative to their sex-specific TD counterparts, both males and females with ASD had smaller regions dedicated to fibers projecting to superior frontal cortex, but patterns differed in callosal subregions projecting to other parts of frontal cortex. While males with ASD had a smaller callosal region dedicated to the orbitofrontal cortex, females with ASD had a smaller callosal region dedicated to the anterior frontal cortex. There were also sex differences in diffusion properties of callosal fibers. While no alterations were observed in males with ASD relative to TD males, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were all increased in females with ASD relative to TD females. Analyses of Witelson subdivisions revealed a decrease in midsagittal area of the corpus callosum in both males and females with ASD but no regional differences in specific subdivisions. Longitudinal analyses revealed no diagnostic or sex differences in the growth rate or change in diffusion measures of the corpus callosum from 3 to 5 years of age. There are sex differences in the pattern of altered corpus callosum neuroanatomy in preschool-aged children with ASD.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Canada 1 <1%
Unknown 154 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 19%
Student > Ph. D. Student 27 17%
Researcher 18 12%
Student > Doctoral Student 14 9%
Student > Bachelor 12 8%
Other 32 21%
Unknown 24 15%
Readers by discipline Count As %
Psychology 35 22%
Neuroscience 30 19%
Medicine and Dentistry 18 12%
Agricultural and Biological Sciences 12 8%
Biochemistry, Genetics and Molecular Biology 7 4%
Other 20 13%
Unknown 34 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2015.
All research outputs
#573,699
of 23,577,654 outputs
Outputs from Molecular Autism
#54
of 684 outputs
Outputs of similar age
#7,098
of 266,033 outputs
Outputs of similar age from Molecular Autism
#5
of 23 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 684 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,033 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.