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Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma

Overview of attention for article published in BMC Research Notes, March 2015
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Identification of regulatory SNPs associated with genetic modifications in lung adenocarcinoma
Published in
BMC Research Notes, March 2015
DOI 10.1186/s13104-015-1053-8
Pubmed ID
Authors

Tzu-Pin Lu, Chuhsing K Hsiao, Liang-Chuan Lai, Mong-Hsun Tsai, Chung-Ping Hsu, Jang-Ming Lee, Eric Y Chuang

Abstract

Although much research effort has been devoted to elucidating lung cancer, the molecular mechanism of tumorigenesis still remains unclear. A major challenge to improve the understanding of lung cancer is the difficulty of identifying reproducible differentially expressed genes across independent studies, due to their low consistency. To enhance the reproducibility of the findings, an integrated analysis was performed to identify regulatory SNPs. Thirty-two pairs of tumor and adjacent normal lung tissue specimens were analyzed using Affymetrix U133plus2.0, Affymetrix SNP 6.0, and Illumina Infinium Methylation microarrays. Copy number variations (CNVs) and methylation alterations were analyzed and paired t-tests were used to identify differentially expressed genes. A total of 505 differentially expressed genes were identified, and their dysregulated patterns moderately correlated with CNVs and methylation alterations based on the hierarchical clustering analysis. Subsequently, three statistical approaches were performed to explore regulatory SNPs, which revealed that the genotypes of 551 and 66 SNPs were associated with CNV and changes in methylation, respectively. Among them, downstream transcriptional dysregulation was observed in 9 SNPs for CNVs and 4 SNPs for methylation alterations. In summary, these identified SNPs concurrently showed the same direction of gene expression changes with genetic modifications, suggesting their pivotal roles in the genome for non-smoking women with lung adenocarcinoma.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 29%
Student > Ph. D. Student 3 21%
Student > Bachelor 2 14%
Student > Doctoral Student 2 14%
Professor > Associate Professor 2 14%
Other 0 0%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 50%
Medicine and Dentistry 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Computer Science 1 7%
Nursing and Health Professions 1 7%
Other 0 0%
Unknown 2 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2020.
All research outputs
#6,417,450
of 22,803,211 outputs
Outputs from BMC Research Notes
#998
of 4,262 outputs
Outputs of similar age
#75,832
of 263,340 outputs
Outputs of similar age from BMC Research Notes
#24
of 76 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 4,262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.