Title |
Fast and scalable inference of multi-sample cancer lineages
|
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Published in |
Genome Biology, May 2015
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DOI | 10.1186/s13059-015-0647-8 |
Pubmed ID | |
Authors |
Victoria Popic, Raheleh Salari, Iman Hajirasouliha, Dorna Kashef-Haghighi, Robert B West, Serafim Batzoglou |
Abstract |
Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer progression from multiple somatic samples. LICHeE uses variant allele frequencies of somatic single nucleotide variants obtained by deep sequencing to reconstruct multi-sample cell lineage trees and infer the subclonal composition of the samples. LICHeE is open-source and available at http://viq854.github.io/lichee . |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Germany | 2 | 1% |
Unknown | 150 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 40 | 26% |
Researcher | 32 | 21% |
Student > Doctoral Student | 16 | 10% |
Student > Bachelor | 11 | 7% |
Student > Master | 10 | 6% |
Other | 19 | 12% |
Unknown | 26 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 39 | 25% |
Agricultural and Biological Sciences | 39 | 25% |
Computer Science | 25 | 16% |
Medicine and Dentistry | 9 | 6% |
Mathematics | 3 | 2% |
Other | 7 | 5% |
Unknown | 32 | 21% |