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Fast and scalable inference of multi-sample cancer lineages

Overview of attention for article published in Genome Biology, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)

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2 Google+ users

Citations

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199 Dimensions

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154 Mendeley
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1 CiteULike
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Title
Fast and scalable inference of multi-sample cancer lineages
Published in
Genome Biology, May 2015
DOI 10.1186/s13059-015-0647-8
Pubmed ID
Authors

Victoria Popic, Raheleh Salari, Iman Hajirasouliha, Dorna Kashef-Haghighi, Robert B West, Serafim Batzoglou

Abstract

Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer progression from multiple somatic samples. LICHeE uses variant allele frequencies of somatic single nucleotide variants obtained by deep sequencing to reconstruct multi-sample cell lineage trees and infer the subclonal composition of the samples. LICHeE is open-source and available at http://viq854.github.io/lichee .

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Germany 2 1%
Unknown 150 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 26%
Researcher 32 21%
Student > Doctoral Student 16 10%
Student > Bachelor 11 7%
Student > Master 10 6%
Other 19 12%
Unknown 26 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 25%
Agricultural and Biological Sciences 39 25%
Computer Science 25 16%
Medicine and Dentistry 9 6%
Mathematics 3 2%
Other 7 5%
Unknown 32 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2015.
All research outputs
#6,754,462
of 25,374,917 outputs
Outputs from Genome Biology
#3,158
of 4,467 outputs
Outputs of similar age
#73,748
of 279,102 outputs
Outputs of similar age from Genome Biology
#65
of 76 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.