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Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Overview of attention for article published in Critical Care, December 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

blogs
1 blog
twitter
13 X users
facebook
2 Facebook pages
wikipedia
1 Wikipedia page

Citations

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90 Dimensions

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mendeley
83 Mendeley
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Title
Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0949-y
Pubmed ID
Authors

Kuo-Chin Kao, Han-Chung Hu, Chih-Hao Chang, Chen-Yiu Hung, Li-Chung Chiu, Shih-Hong Li, Shih-Wei Lin, Li-Pang Chuang, Chih-Wei Wang, Li-Fu Li, Ning-Hung Chen, Cheng-Ta Yang, Chung-Chi Huang, Ying-Huang Tsai

Abstract

Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. This study is designed to investigate the role of DAD in ARDS patients who underwent open lung biopsy. We retrospectively reviewed all ARDS patients who met the Berlin definition and underwent open lung biopsy from January 1999 to January 2014 in a referred medical center. DAD is characterized by hyaline membrane formation, lung edema, inflammation, hemorrhage and alveolar epithelial cell injury. Clinical data including baseline characteristics, severity of ARDS, clinical and pathological diagnoses, and survival outcomes were analyzed. A total of 1838 patients with ARDS were identified and open lung biopsies were performed on 101 patients (5.5 %) during the study period. Of these 101 patients, the severity of ARDS on diagnosis was mild of 16.8 %, moderate of 56.5 % and severe of 26.7 %. The hospital mortality rate was not significant difference between the three groups (64.7 % vs 61.4 % vs 55.6 %, p = 0.81). Of the 101 clinical ARDS patients with open lung biopsies, 56.4 % (57/101) patients had DAD according to biopsy results. The proportion of DAD were 76.5 % (13/17) in mild, 56.1 % (32/57) in moderate and 44.4 % (12/27) in severe ARDS and there is no significant difference between the three groups (p = 0.113). Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). Pathological findings of DAD (odds ratio: 3.554, 95 % CI, 1.385-9.12; p = 0.008) and Sequential Organ Failure Assessment score on the biopsy day (odds ratio: 1.424, 95 % CI, 1.187-1.707; p<0.001) were significantly and independently associated with hospital mortality. The baseline demographics and clinical characteristics were not significantly different between DAD and non-DAD patients. The correlation of pathological findings of DAD and ARDS diagnosed by Berlin definition is modest. A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
United States 1 1%
Brazil 1 1%
Unknown 80 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 13%
Researcher 9 11%
Student > Postgraduate 9 11%
Student > Doctoral Student 6 7%
Professor 6 7%
Other 25 30%
Unknown 17 20%
Readers by discipline Count As %
Medicine and Dentistry 47 57%
Agricultural and Biological Sciences 5 6%
Biochemistry, Genetics and Molecular Biology 2 2%
Physics and Astronomy 2 2%
Engineering 2 2%
Other 2 2%
Unknown 23 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2020.
All research outputs
#2,062,994
of 25,374,647 outputs
Outputs from Critical Care
#1,850
of 6,554 outputs
Outputs of similar age
#33,629
of 395,408 outputs
Outputs of similar age from Critical Care
#137
of 466 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.