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Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells

Overview of attention for article published in Epigenetics & Chromatin, October 2011
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Title
Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells
Published in
Epigenetics & Chromatin, October 2011
DOI 10.1186/1756-8935-4-17
Pubmed ID
Authors

Tatyana B Nesterova, Claire E Senner, Janina Schneider, Tilly Alcayna-Stevens, Anna Tattermusch, Myriam Hemberger, Neil Brockdorff

Abstract

Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcription factors Nanog, Oct4 and Sox2 are implicated in Xist gene extinction, at least in part through binding to an element located in Xist intron 1. Other pathways, notably repression by the antisense RNA Tsix, may also be involved.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Portugal 1 2%
Germany 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 23%
Researcher 12 20%
Student > Master 10 16%
Student > Bachelor 6 10%
Professor > Associate Professor 6 10%
Other 9 15%
Unknown 4 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 54%
Biochemistry, Genetics and Molecular Biology 17 28%
Medicine and Dentistry 3 5%
Immunology and Microbiology 1 2%
Environmental Science 1 2%
Other 0 0%
Unknown 6 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2011.
All research outputs
#20,147,309
of 22,653,392 outputs
Outputs from Epigenetics & Chromatin
#519
of 563 outputs
Outputs of similar age
#124,726
of 135,640 outputs
Outputs of similar age from Epigenetics & Chromatin
#5
of 5 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,640 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.