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Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease

Overview of attention for article published in Arthritis Research & Therapy, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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5 X users
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1 patent
reddit
1 Redditor

Citations

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56 Dimensions

Readers on

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77 Mendeley
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Title
Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease
Published in
Arthritis Research & Therapy, May 2015
DOI 10.1186/s13075-015-0645-y
Pubmed ID
Authors

Lisa M Mullen, Giselle Chamberlain, Sandra Sacre

Abstract

The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to tissues. In particular, the Toll-like receptors and nucleotide-binding oligomerisation domain-like receptors that form inflammasomes have been postulated as key contributors to the inflammation observed in rheumatoid arthritis, osteoarthritis, gout and systemic lupus erythematosus. As such, there is increasing interest in targeting these receptors for therapeutic treatment in the clinic. Here the role of pattern recognition receptors in the pathogenesis of these diseases is discussed, with an update on the development of interventions to modulate the activity of these potential therapeutic targets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Brazil 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 22%
Student > Ph. D. Student 9 12%
Student > Bachelor 8 10%
Student > Doctoral Student 7 9%
Student > Master 5 6%
Other 14 18%
Unknown 17 22%
Readers by discipline Count As %
Medicine and Dentistry 20 26%
Biochemistry, Genetics and Molecular Biology 12 16%
Immunology and Microbiology 6 8%
Agricultural and Biological Sciences 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 8 10%
Unknown 22 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2020.
All research outputs
#6,238,666
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#1,367
of 3,381 outputs
Outputs of similar age
#67,802
of 279,384 outputs
Outputs of similar age from Arthritis Research & Therapy
#29
of 68 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,384 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.