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Improved disease markers suggest dual response in a patient with metastatic castration resistant prostate cancer and chronic lymphocytic leukemia following active cellular immunotherapy

Overview of attention for article published in Journal of Hematology & Oncology, May 2015
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Title
Improved disease markers suggest dual response in a patient with metastatic castration resistant prostate cancer and chronic lymphocytic leukemia following active cellular immunotherapy
Published in
Journal of Hematology & Oncology, May 2015
DOI 10.1186/s13045-015-0149-x
Pubmed ID
Authors

Heather H. Cheng, Colleen Soleau, Evan Y. Yu

Abstract

Prostate cancer and chronic lymphocytic leukemia (CLL) are relatively common malignancies associated with advanced age. Although immunotherapy-based strategies are used to treat both, currently, there is no overlap in specific therapies. Sipuleucel-T is an active cellular immunotherapy that improves overall survival for patients with metastatic castration resistant prostate cancer (mCRPC) but is not typically associated with a decline in prostate-specific antigen (PSA) following administration. We report the case of a 78-year-old man with mCRPC and Rai stage 0 CLL who sustained a 12-month decline in both PSA and white blood cell (WBC) count following treatment with APC8015-2 (an investigational form of sipuleucel-T), as part of the phase II ProACT clinical trial. Two years later, the patient received commercial sipuleucel-T and again was noted to have a decline in PSA. Exploratory analysis did not clearly identify any peripheral immune markers associated with response. This case report suggests that treatment with sipuleucel-T can rarely lead to PSA decline, may have dual activity against both prostate cancer and CLL, and that these findings warrant further investigation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 15%
Student > Bachelor 4 15%
Student > Ph. D. Student 4 15%
Lecturer 2 7%
Student > Master 2 7%
Other 4 15%
Unknown 7 26%
Readers by discipline Count As %
Medicine and Dentistry 10 37%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Mathematics 1 4%
Nursing and Health Professions 1 4%
Arts and Humanities 1 4%
Other 4 15%
Unknown 8 30%