Title |
Timing the origin of human malarias: the lemur puzzle
|
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Published in |
BMC Ecology and Evolution, October 2011
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DOI | 10.1186/1471-2148-11-299 |
Pubmed ID | |
Authors |
M Andreína Pacheco, Fabia U Battistuzzi, Randall E Junge, Omar E Cornejo, Cathy V Williams, Irene Landau, Lydia Rabetafika, Georges Snounou, Lisa Jones-Engel, Ananias A Escalante |
Abstract |
Timing the origin of human malarias has been a focus of great interest. Previous studies on the mitochondrial genome concluded that Plasmodium in primates, including those parasitic to humans, radiated relatively recently during a process where host switches were common. Those investigations, however, assumed constant rate of evolution and tightly bound (fixed) calibration points based on host fossils or host distribution. We investigate the effect of such assumptions using different molecular dating methods. We include parasites from Lemuroidea since their distribution provides an external validation to time estimates allowing us to disregard scenarios that cannot explain their introduction in Madagascar. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Netherlands | 1 | 1% |
Pakistan | 1 | 1% |
Colombia | 1 | 1% |
Finland | 1 | 1% |
Kenya | 1 | 1% |
Romania | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 91 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 22% |
Student > Ph. D. Student | 21 | 21% |
Student > Master | 17 | 17% |
Student > Bachelor | 12 | 12% |
Student > Doctoral Student | 6 | 6% |
Other | 11 | 11% |
Unknown | 11 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 49 | 49% |
Biochemistry, Genetics and Molecular Biology | 12 | 12% |
Medicine and Dentistry | 6 | 6% |
Computer Science | 5 | 5% |
Environmental Science | 4 | 4% |
Other | 8 | 8% |
Unknown | 16 | 16% |