Title |
NF-κB and IRF pathways: cross-regulation on target genes promoter level
|
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Published in |
BMC Genomics, April 2015
|
DOI | 10.1186/s12864-015-1511-7 |
Pubmed ID | |
Authors |
Marta Iwanaszko, Marek Kimmel |
Abstract |
The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. These findings agree with recent experimental data reporting crosstalk between pathways activated by RIG-I and TLR3 receptors in response to pathogens. We present an extended crosstalk diagram of the IRF - NF-κB pathways. We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 177 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 17% |
Student > Master | 25 | 14% |
Researcher | 24 | 14% |
Student > Bachelor | 23 | 13% |
Student > Doctoral Student | 9 | 5% |
Other | 19 | 11% |
Unknown | 47 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 45 | 25% |
Agricultural and Biological Sciences | 25 | 14% |
Immunology and Microbiology | 23 | 13% |
Medicine and Dentistry | 9 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 16 | 9% |
Unknown | 53 | 30% |