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Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in Juvenile-onset Systemic Lupus Erythematosus

Overview of attention for article published in Pediatric Rheumatology, April 2015
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Title
Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in Juvenile-onset Systemic Lupus Erythematosus
Published in
Pediatric Rheumatology, April 2015
DOI 10.1186/s12969-015-0007-y
Pubmed ID
Authors

Lucy Ballantine, Angela Midgley, David Harris, Ella Richards, Sarah Burgess, Michael W Beresford

Abstract

The TAM-receptor tyrosine kinase family, Tyro3, Axl and Mer are key to apoptotic cell clearance. Reduced phagocytic clearance in systemic lupus erythematosus (SLE) leads to prolonged exposure of nuclear autoantigen to the immune system. Here we measure the levels of TAM receptors and the phagocytic capacity of monocytes and macrophages in juvenile-onset SLE (JSLE). Mer protein was measured on monocytes from JSLE, healthy control and JIA patients. JSLE, healthy control and JIA patients' plasma were analysed for soluble Mer (sMer), soluble Tyro3 (sTyro) and soluble Axl (sAxl). A phagocytosis assay measured the effect of JSLE serum on phagocytic potential of JSLE and control monocytes to engulf E. Coli bacteria and healthy macrophages to engulf apoptotic neutrophils. Mer receptor expression was significantly decreased on JSLE monocytes compared to healthy controls. Plasma sMer, sTyro and sAxl were significantly increased in JSLE patients compared to controls (p < 0.05). Adult healthy control macrophages had significantly decreased phagocytosis of E. Coli and apoptotic neutrophils in the presence of 10% JSLE serum compared to control serum (p < 0.05). JSLE patients have a decreased phagocytosis due to both serum and cell-derived factors. Significantly increased levels of sMer, sTyro3 and sAxl may be important factors contributing to the deficit in phagocytosis ability.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Canada 2 3%
Singapore 1 2%
United Kingdom 1 2%
Unknown 53 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Ph. D. Student 9 15%
Student > Bachelor 6 10%
Student > Master 6 10%
Student > Doctoral Student 3 5%
Other 8 14%
Unknown 14 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 22%
Agricultural and Biological Sciences 13 22%
Medicine and Dentistry 10 17%
Immunology and Microbiology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 4 7%
Unknown 13 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2015.
All research outputs
#17,758,492
of 22,805,349 outputs
Outputs from Pediatric Rheumatology
#527
of 695 outputs
Outputs of similar age
#180,254
of 264,165 outputs
Outputs of similar age from Pediatric Rheumatology
#3
of 4 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 695 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,165 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.